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Mushroom Biotechnology for Improved Agriculture and Human Health

Edited by Charles Oluwaseun Adetunji, Chukwuebuka Egbuna, Oluwatosin Ademola Ijabadeniyi and Samantha C. Karunarathna
Copyright: 2025   |   Expected Pub Date:2025/03/28
ISBN: 9781394212637  |  Hardcover  |  
392 pages

One Line Description
The book is essential for those seeking to understand innovative and sustainable
solutions to global food insecurity and health challenges, as it offers invaluable insights into the transformative potential of mushroom biotechnology and its applications.

Audience
The book is valuable reference work for scientists and researchers working in the fields of pharmaceutical sciences, agricultural microbiology, plant pathology, botany, agriculture, microbiology, biotechnology, nanotechnology, environmental microbiology, and microbial biotechnology.

Description
The intervention of microbial biotechnology in various sectors has displayed remarkable growth linked to sustainable innovations and biotechnological utilization of beneficial microorganisms, such as mushrooms, for the benefit of humanity. Recent advancements in mushroom biotechnology will prove successful due to mushrooms’ nature as natural problem solvers, including their ability to enhance nutritional values obtained from agricultural crops, sustained health benefits derived from pharmacologically active substances used to manage human diseases, and improve crop production.
This book will serve as one of the first volumes addressing the usefulness of mushroom biotechnology, giving detailed state-of-the-art information on recent advancements and how the industry could maximize profits. The volume will also assist the pharmaceutical and medical sectors by examining the discovery of novel pharmacological and bioactive compounds that could replace the various adverse effects when using synthetic drugs. It presents a simple, adaptable, reproducible methodology that will help researchers and scientists adopt these methodologies for similar projects.
Readers will find that the book:
•Presents recent advances in the application of mushroom biotechnology in various sectors (food, agriculture, and health) for sustainable innovations for optimum benefit of mankind;
•Details applications of mushrooms for sustainable agriculture through their plant growth-promoting attributes and management of pests and diseases in plants and soils;
•Discusses the discovery of novel pharmacological substances from mushrooms for applications in the biomedical sector.

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Author / Editor Details
Charles Oluwaseun Adetunji, PhD, is a professor in the Department of Microbiology at the Edo University Iyamho, in Edo State, Nigeria. Currently, he is the Director of Intellectual Properties and Technology Transfer and Chairman of the Committee on Research Grants at EUI. He has won several scientific awards and grants from renowned academic bodies such as the Council of Scientific and Industrial Research (CSIR) India. He has published more than 600 papers in peer-reviewed national and international journals as well as more than 50 books, 340 book chapters, and many scientific patents.

Chukwuebuka Egbuna, PhD, is a chartered chemist and academic researcher. He has published numerous articles in international journals of repute and edited over 20 internationally published books. He serves as a reviewer and editorial board member of several journals and a member of the Institute of Chartered Chemists of Nigeria, the Nigerian Society of Biochemistry and Molecular Biology, and the Royal Society of Chemistry. His primary research interests include biochemistry, phytochemistry, pharmacology, nutrition and toxicology, food and medicinal chemistry, and analytical biochemistry.

Oluwatosin Ademola Ijabadeniyi, PhD, is a professor in the Department of Biotechnology and Food Science, Durban University of Technology, South Africa. He has published numerous scientific papers, edited one book, and authored four books. His work in this field has also earned him several awards including an Association of Commonwealth Universities fellowship and an Association of Public Health Libraries Centers for Disease Control fellowship.

Samantha C. Karunarathna, PhD, is a professor at Qujing Normal University, China. He has published over 360 publications and co-authored two books. His current research interests are taxonomy, phylogeny, and domestication of wild edible and medicinal mushrooms.

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Table of Contents
Preface
1. Application of Mushrooms in the Bioremediation of Environmental Pollutants
Isibor Patrick Omoregie, Oluwafemi Adebayo Oyewole, Kayode-Edwards Ihotu, Agbontaen Osagie David, Konjerimam Ishaku Chimbekujwo, Simon Sunday Ameh,
Samuel Adeniyi Oyegbade and Charles Oluwaseun Adetunji
Introduction
Unique Characteristics of Fungi
Specific Contaminants Targeted by Mushrooms
Mechanisms of Mushroom Bioremediation
Absorption and Accumulation of Contaminants by Mushrooms
Transformation and Degradation of Pollutants
Role of Enzymes and Metabolic Processes
Advancements and Research in Mushroom Bioremediation
Emerging Trends in Fungal Bioremediation
Genetic Modification of Mushrooms for Enhanced Bioremediation
Benefits of Mushroom Bioremediation
Challenges and Limitations of Using Mushrooms
Future Prospects and Research Opportunities
Conclusion and Recommendations
References
2. Application of Mushroom in the Management of Pest and Diseases Affecting Agricultural Crops
Ruth Ebunoluwa Bodunrinde, Konjerimam Ishaku Chimbekujwo, Oluwafemi Adebayo Oyewole, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola, John Tsado Mathew and Adeyomoye Olorunsola Israel
2.1 Introduction
2.2 Properties of Mushroom as Biocontrol Agents (Basidiomycetes)
2.3 Mushroom Substrate as Biocontrol Agent for Plant
2.4 Mechanism of Action of Mushrooms in the Control of Pests and Diseases
2.5 Several Areas Where Mushrooms Can Be Applied
2.6 Mushrooms as Disease Control Agents
2.7 Conclusion
References
3. Agricultural Applications of Novel Mushroom-Based Nanopesticide
Isibor Patrick Omoregie, Oluwafemi Adebayo Oyewole, Adamu Binta Buba, Alhassan Muhammad Alhassan and Charles Oluwaseun Adetunji
3.1 Introduction
3.2 Advantages of Nanobiopesticides Over Conventional Pesticides
3.3 Mushrooms as Nanobiopesticide Sources
3.4 Bioactive Compounds in Mushrooms Suitable for Nanobiopesticide Development
3.5 Role of Mushroom Extracts in Nanoparticle Synthesis
3.6 Mechanisms of Action of Nanobiopesticides on Pests and Pathogens
3.7 Production and Formulation of Nanobiopesticides
3.8 Agricultural Applications of Nanobiopesticides
3.9 Future Prospects and Research Directions
3.10 Recommendation and Conclusion
References
4. Mass Production of Mushroom for Animal Feed
Konjerimam Ishaku Chimbekujwo, Ruth Ebunoluwa Bodunrinde, Oluwafemi Adebayo Oyewole, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola, John Tsado Mathew and Adeyomoye Olorunsola Israel
4.1 Introduction
4.2 Mushroom
4.3 Mushroom Production
4.3.1 Mass Production of Mushrooms for Animal Feed
4.3.2 Mushroom Substrate (Spent) for Feed
4.3.3 Mushroom Substrate (Spent) for Poultry
4.3.4 Mushroom Substrate (Spent) for Ruminants
4.4 Benefits of Feeding Animals with Mushrooms
4.5 Conclusion
References
5. Application of Mushrooms in Management of Soil-Borne Parasites, Nematodes, Bacteria and Fungi
Aisha Bisola Bello, Abdullahi Idris Dabban, Wuna Muhammad Muhammad, Adioha Amarachi, Joseph Odey Oko, Hammed Opeyemi, Oluwafemi Adebayo Oyewole and Charles Oluwaseun Adetunji
5.1 Introduction
5.2 Soil-Borne Parasites, Nematodes, Bacteria, and Fungi
5.2.1 Soil-Borne Nematodes
5.2.2 Types of Soil-Borne Bacteria
5.2.3 Types of Soil-Borne Fungi
5.3 Mushrooms as Biocontrol Agents
5.3.1 Mushrooms as Natural Biopesticide
5.3.2 Mechanisms of Mushroom-Mediated Biocontrol
5.4 Mushroom Species and Biocontrol Potential
5.5 Advantages of Mushroom Biocontrol
5.6 Challenges and Limitations of Mushroom Bio-Control
5.7 Conclusion and Future Outlook
References
6. Production of Stable Enzymes from Mushrooms with Numerous Biomedical Applications
Idris Abdullahi Dabban, Olorunshola Lucky Opeyemi, Mustapha Adamu, Bashaku Yakubu Dabban, Auwalu Bala, Oyegbade Samuel Adeniyi, Oluwafemi Adebayo Oyewole and Charles Oluwaseun Adetunji
6.1 Introduction
6.2 Classes/Types of Mushrooms
6.2.1 Button Mushroom (Agaricus bisporus)
6.2.2 Oyster (Pleurotus ostreatus)
6.2.3 Portabello
6.2.4 Morel (Morchella)
6.2.5 Reishi (Ganoderma lucidum)
6.2.6 Burnt Matches (Eutypellascorpia)
6.2.7 Chanterelle (Cantharellus)
6.2.8 Laetiporus sulphureus
6.2.9 Cordyceps (Cordyceps militaris)
6.2.10 Enokitake (Flammulina velutipes)
6.2.11 Giraffe Spots (Endophora albobadia)
6.2.12 Destroying Angel (Amanita sp.)
6.2.13 Green-Spored Lepiota (Chloropyhllum)
6.2.14 Matsutake Mushroom
6.2.15 Shiitake Mushroom (Lentinula edodes)
6.2.16 Truffles
6.2.17 Shimeji
6.3 Stable Enzymes Produced by Mushrooms
6.3.1 Ligninolytic Enzymes
6.3.1.1 Lignin Peroxidase
6.3.1.2 Manganese Peroxidase
6.3.1.3 Versatile Peroxidase
6.3.1.4 Laccases
6.3.1.5 Tyrosinase
6.3.2 Hydrolases
6.3.2.1 Cellulases
6.3.2.2 Xylanase
6.3.2.3 Pectinases
6.3.2.4 Amylases
6.3.2.5 Proteases
6.3.2.6 Esterase
6.3.3 Stress Enzymes
6.4 Biomedical and Biotechnological Applications of Stable Mushroom Enzymes
6.4.1 Mushroom Enzymes as Antimicrobial Agents
6.4.2 Mushroom Enzymes as Anticancer and Antitumor Agents
6.4.3 Mushroom Enzymes as Antioxidants
6.4.4 Other Applications of Mushroom Enzymes
6.5 Some Limitations of Mushroom Enzymes
6.6 Conclusion and Future Perspectives
References
7. Relevance of Mushrooms for Biological Control of Diverse Biotic Agent Mitigating Against Agricultural Crops
Oluwabukola Atinuke Popoola, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Abel Inobeme and Adeyomoye Olorunsola Israel
7.1 Introduction
7.1.1 Benefits of Using Mushrooms in Pest and Disease Management
7.1.2 Challenges of Mycopesticides
7.2 Fungal Biopesticides
7.2.1 How Fungal Biopesticides Work
7.2.2 Advantages of Fungal Biopesticides
7.2.3 Challenges and Considerations of Fungal Biopesticides
7.2.4 Some Key Points Regarding Fungal Biopesticides
7.3 Mycoparasitism
7.4 Nutrient Cycling and Soil Health
7.5 Companion Planting
7.6 Challenges and Considerations
7.7 Conclusion and Future Perspectives
7.7.1 Future Perspectives
References
8. Discovery and Relevance of Novel Pharmacological Substances from Beneficial Mushrooms
Oluwabukola Atinuke Popoola, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Abel Inobeme and Adeyomoye Olorunsola Israel
8.1 Introduction
8.1.1 Brief Overview of Beneficial Mushrooms
8.1.2 Importance of Discovering Novel Pharmacological Substances in Mushrooms
8.1.3 Beneficial Mushrooms as a Source of Pharmacological Substances
8.1.4 Historical Use of Mushrooms in Traditional Medicine
8.2 Bioactive Compounds in Mushrooms
8.3 Pharmacological Activities of Mushroom-Derived Compounds
8.4 Clinical Applications and Relevance
8.5 Challenges and Future Directions
Conclusion
References
9. Application of Mushroom in the Management of Diabetes Mellitus
Adeyomoye Olorunsola Israel, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Oluwabukola Atinuke Popoola and John Tsado Mathew
Introduction
Pathophysiology of Diabetes Mellitus
Mushroom and Its Biomolecules
Mushroom and Health
Therapeutic Potential of Mushroom in the Management of Diabetes Mellitus
Conclusion
References
10. Application of Mushrooms in the Management of Cardiovascular Diseases
Enitan Emmanuella Lawal, Frances Iseghohi, Aishat Sani Rabiu, Amarachi Rosemary Osi, Oluwafemi Adebayo Oyewole, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola, and Adeyomoye Olorunsola Israel
10.1 Introduction
10.2 Selected Medicinal Mushrooms
10.2.1 Ganoderma lucidum
10.2.2 Hericium erinaceus (Lions Mane Mushroom)
10.2.3 Agaricus bisporus
10.3 Nutritional Composition of Mushrooms
10.4 Bioactive Compounds in Mushrooms
10.4.1 The Polysaccharide
10.4.2 Terpenoids
10.4.3 Steroids
10.4.4 Phenolics
10.4.5 Alkaloids
10.5 Cardioprotective Effect of Mushrooms
10.6 Conclusion
References
11. Application of Mushroom in the Regulation of Gut Microbiome and Maintenance of Gut Health
Adeyomoye Olorunsola Israel, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Oluwabukola Atinuke Popoola and John Tsado Mathew
Introduction
Gut Microbiome in Health and Disease
Mushrooms and Their Derived Bioactive Molecules
Health Benefits of Edible Mushroom Associated with Maintenance of Gut Health
Conclusion
References
12. Applications of Mushrooms in the Management of Cancers
Tsado Priscilla Yetu, Iseghohi Frances, Sani Rabiu Aishat, Oluwafemi Adebayo Oyewole, Idris Abdullahi Dabban, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola and Adeyomoye Olorunsola Israel
12.1 Introduction
12.2 Cancer
12.2.1 Types of Cancer
12.3 Mushrooms
12.3.1 Major Bioactive Compounds in Medicinal Mushroom
12.3.1.1 Metabolites with a Substantial Molecular Weight
12.3.1.2 Metabolites with a Low Molecular Weight
12.3.1.3 Polyphenolic Compounds (Styrylpyrone-Class of Phenols)
12.3.2 Mechanisms by Which Certain Mushrooms Exhibit Anti-Cancer Effects
12.3.2.1 Immune Modulation
12.3.2.2 Angiogenesis
12.3.2.3 DNA Repair Inhibition
12.3.2.4 Apoptosis
12.3.2.5 Metastasis
12.3.3 Some Mushrooms and Their Anti-Cancer Properties
12.3.3.1 Agaricus bisporus
12.3.3.2 Antrodia cinnamomea
12.3.3.3 Cordyceps sinensis
12.3.3.4 Coriolus versicolor
12.3.3.5 Ganoderma lucidum
12.3.3.6 Grifola frondosa (Maitake)
12.3.3.7 Lentinula edodes (Shitake)
12.3.3.8 Pleurotus ostreatus (Jacq.)
12.3.4 Exploring Novel Mushroom-Derived Therapies for Cancer
12.3.4.1 Vaccinotherapy
12.3.4.2 Nanovectors for Drug Delivery
12.4 Conclusion
References
13. Applications of Mushrooms as Immune Boosters
Margaret Ikhiwili Oniha, Clement Shina Olusanya, Oluwafemi Adebayo Oyewole, Priscilla Yetu Tsado, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola and Adeyomoye Olorunsola Israel
13.1 Introduction
13.2 Mushroom Composites
13.3 β-Glucans and Their Nutritional Components
13.4 Antiproliferative and Other Human Health Reactions of Medicinal Mushrooms
Conclusion
References
14. The Influence of Mushroom on the Taphonomic Process of Cadaver
Willy Barinem Vidona, Charles Oluwaseun Adetunji and Charity Willy-Vidona
14.1 Introduction
14.2 Mushroom and the Fungus Phylogeny
14.3 Mushroom Taphonomic Process
14.4 Influence of Mushroom on Cadaver Taphonomy
14.5 Conclusion
References
15. Role of Nanobiopesticides Derived from Mushrooms: Recent Advances John Tsado Mathew, Charles Oluwaseun Adetunji, Abel Inobeme, Abdulfatai Aideye Otori, Elijah Yanda Shaba, Musah Monday, Yakubu Azeh, Jibrin Noah Akoji, Amos Mamman, Oluwafemi Adebayo Oyewole, Eniola K. I. T. and Mohammed Bello Yerima
15.1 Introduction
15.2 Environmental and Health Concerns with Chemical Pesticides
15.3 Mushrooms as a Source of Bioactive Compounds
15.4 Antimicrobial and Insecticidal Properties of Mushrooms
15.4.1 Antimicrobial Properties
15.4.2 Antiparasitic Activity
15.5 Nanotechnology and its Applications in Agriculture
15.6 Mechanisms of Action of Nanobiopesticides
15.7 Benefits and Advantages of Nanobiopesticides
15.8 Conclusion and Future Perspectives
15.8.1 Conclusion
15.8.2 Future Perspectives
References
16. Nutraceutical, Mineral, Proximate Constituents from Beneficial Mushrooms
John Tsado Mathew, Abel Inobeme, Charles Oluwaseun Adetunji, Abdulfatai Aideye Otori, Elijah Yanda Shaba, Musah Monday, Yakubu Azeh, Ismail Haruna, Amos Mamman, Jemkur Maurice, Oluwafemi Adebayo Oyewole, Eniola K. I. T. and Mohammed Bello Yerima
16.1 Introduction
16.2 Nutraceutical Constituents of Mushrooms
16.3 Mineral Constituents of Mushrooms
16.4 Proximate Constituents of Mushrooms
16.5 Variation among Mushroom Species
16.6 Health Implications and Potential Benefits
16.7 Conclusion
References
17. Application of Mushrooms in the Promotion of Longevity
Victory Igiku, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Eniola K.I.T. and Mohammed Bello Yerima
17.1 Introduction
17.2 Health Benefits of Mushrooms
17.3 Conclusion
References
Index

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Description
Author/Editor Details
Table of Contents
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