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Submit a ProposalPlant-Based Phytochemicals V2
 | Volume 2 Pharmacological Studies in Male Disorders Edited by Durgesh Nandini Chauhan and Nagendra Singh Chauhan Copyright: 2026 | Expected Pub Date:2026/06/30 ISBN: 9781394272150 | Hardcover | 442 pages |
One Line Description
Master the next generation of evidence-based therapies for male-specific conditions with this definitive guide to the mechanisms, efficacy, and clinical potential of bioactive natural products.
Audience
Academics, researchers, and healthcare professionals studying medical, pharmacy, and life sciences, specifically microbiology, pharmaceutical biotechnology, pharmaceutics, medicinal chemistry, and natural sciences.
Academics, researchers, and healthcare professionals studying medical, pharmacy, and life sciences, specifically microbiology, pharmaceutical biotechnology, pharmaceutics, medicinal chemistry, and natural sciences.
Description
Today, the population is facing a growing number of health concerns, including cancer and hormonal and reproductive disorders, that complicate everyday life. As these concerns become more prevalent, individuals are looking for not only traditional but also alternative treatments for these ailments. Natural products may provide a safer, holistic, and sustainable approach to treating these disorders. While they may not replace conventional treatments entirely, they can serve as effective complementary therapies to improve overall health. However, proper dosage, clinical validation, and consultation with healthcare professionals are essential for safe and effective use. This two-volume set highlights the potential of natural products as effective treatments.
With the rising prevalence of male-specific health conditions, including androgenetic alopecia, benign prostatic hyperplasia, and sexual dysfunction, there is a critical need for evidence-based therapeutic alternatives. This volume provides an in-depth analysis of the role of bioactive natural products in the
prevention and management of these disorders, highlighting the use of plant-based, herbal, and marinederived substances. Featuring contributions from leading researchers, the text adopts an interdisciplinary perspective to explore the mechanisms, efficacy, and clinical potential of emerging natural treatments,
focusing on their anti-inflammatory, antioxidant, and immunomodulatory properties. It serves as a definitive resource for scholars and practitioners dedicated to the advancement of male medicine through natural product chemistry.
Readers will find the volume:
• Offers comprehensive investigations of phytochemical-based medicines and natural products for the treatment of male disorders;
• Explores the mechanism of action in various diseases, and the role of natural products and alternative systems of medicine formulation through preclinical and clinical studies;
• Covers foundational principles of the latest advancements in natural treatments for male-specific disorders.
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Today, the population is facing a growing number of health concerns, including cancer and hormonal and reproductive disorders, that complicate everyday life. As these concerns become more prevalent, individuals are looking for not only traditional but also alternative treatments for these ailments. Natural products may provide a safer, holistic, and sustainable approach to treating these disorders. While they may not replace conventional treatments entirely, they can serve as effective complementary therapies to improve overall health. However, proper dosage, clinical validation, and consultation with healthcare professionals are essential for safe and effective use. This two-volume set highlights the potential of natural products as effective treatments.
With the rising prevalence of male-specific health conditions, including androgenetic alopecia, benign prostatic hyperplasia, and sexual dysfunction, there is a critical need for evidence-based therapeutic alternatives. This volume provides an in-depth analysis of the role of bioactive natural products in the
prevention and management of these disorders, highlighting the use of plant-based, herbal, and marinederived substances. Featuring contributions from leading researchers, the text adopts an interdisciplinary perspective to explore the mechanisms, efficacy, and clinical potential of emerging natural treatments,
focusing on their anti-inflammatory, antioxidant, and immunomodulatory properties. It serves as a definitive resource for scholars and practitioners dedicated to the advancement of male medicine through natural product chemistry.
Readers will find the volume:
• Offers comprehensive investigations of phytochemical-based medicines and natural products for the treatment of male disorders;
• Explores the mechanism of action in various diseases, and the role of natural products and alternative systems of medicine formulation through preclinical and clinical studies;
• Covers foundational principles of the latest advancements in natural treatments for male-specific disorders.
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Author / Editor Details
Durgesh Nandini Chauhan has several years of academic experience that are demonstrated in her position at the Columbia College of Pharmacy, Raipur, Chhattisgarh, India. She has written more than 10 articles published in national and international journals, 15 book chapters, and edited 10 books. Her teaching focuses on subjects such as pharmaceutics, pharmacognosy, traditional concepts of medicinal plants, drug delivery, phytochemistry, cosmetic technology, and pharmaceutical engineering.
Durgesh Nandini Chauhan has several years of academic experience that are demonstrated in her position at the Columbia College of Pharmacy, Raipur, Chhattisgarh, India. She has written more than 10 articles published in national and international journals, 15 book chapters, and edited 10 books. Her teaching focuses on subjects such as pharmaceutics, pharmacognosy, traditional concepts of medicinal plants, drug delivery, phytochemistry, cosmetic technology, and pharmaceutical engineering.
Nagendra Singh Chauhan, PhD is a Senior Scientific Officer and Government Analyst at the Avam Anusandhan Kendra Drug Testing Laboratory, Raipur, Chhattisgarh, India. His more than 20 years of research experience is reflected in his roles across a number of professional societies. He has written
more than 70 articles in national and international journals, 32 book chapters, and edited seven books. His research focuses on natural product isolation and phytopharmacology.
more than 70 articles in national and international journals, 32 book chapters, and edited seven books. His research focuses on natural product isolation and phytopharmacology.
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Table of Contents
Preface
1. Natural Products for the Treatment of Testicular Cancer
Harpreet Singh, Himanshu Sharma, Rashmi Pathak, Amit Anand, Arvind Kumar, Amrita Mishra and Arun Kumar Mishra
1.1 Introduction
1.2 Promising Natural Products for Testicular Cancer
1.2.1 Plant-Derived Compounds
1.2.1.1 Alkaloids
1.2.1.2 Polyphenols
1.2.2 Marine-Derived Compounds
1.2.2.1 Marine Algae Compounds
1.2.2.2 Marine Invertebrate-Derived Compounds
1.2.3 Herbal Remedies from Traditional Medicine
1.2.3.1 Traditional Chinese Medicine
1.2.3.2 Ayurveda
1.2.3.3 Indigenous Healing Practices
1.3 Mechanisms of Action of Natural Products in Testicular Cancer
1.3.1 Induction of Apoptosis
1.3.2 Inhibition of Angiogenesis
1.3.3 Modulation of Signaling Pathways
1.3.4 Immune System Activation
1.3.5 Antioxidant and Anti-Inflammatory Effects
1.4 Preclinical Studies and In Vitro Evidence
1.4.1 Animal Models of Testicular Cancer
1.4.2 Cell Line Studies
1.4.3 Biochemical Assays and Molecular Investigations
1.4.4 Synergistic Effects of Conventional Treatments
1.5 Clinical Trials and Human Studies
1.5.1 Phase I, II, and III Clinical Trials
1.5.2 Safety and Efficacy of Natural Products
1.5.3 Patient Outcomes and Quality of Life
1.6 Role of Natural Products in Testicular Cancer
1.6.1 Emerging Natural Products for Testicular Cancer
1.6.2 Combination Therapies
1.6.3 Personalized Medicine Approaches
1.7 Future Prospects
1.8 Conclusion
References
2. Natural Products for the Treatment of Male Sexual Dysfunction
Subhiksha. S., Akash. J., B. Siva Kumar and K. Ilango
2.1 Introduction
2.2 Male Reproductive System
2.3 The Physiological Process of Achieving an Erection
2.4 Natural Substances that can Enhance Sexual Desire and Performance
2.4.1 Alpiniacalcarata Roscoe (Zingiberaceae)
2.4.2 Anacyclus pyrethrum DC (Asteraceae)
2.4.3 Asparagus racemosus (Liliaceae)
2.4.4 Allium sativum (Alliaceae)
2.4.5 Anethum graveolens L. (Apiaceae)
2.4.6 Butea frondosa Koenig ex Roxb. (Papilionaceae)
2.4.7 Blepharis (Acanthaceae)
2.4.8 Butea superba (Leguminosae)
2.4.9 Curculigo orchioides (Hypoxidaceae)
2.4.10 Durio zibenthinus (Bombacaceae)
2.4.11 Eurycoma longifolia jack (Simaroubaceae)
2.4.12 Glycyrrhiza glabra (Leguminoaceae)
2.4.13 Kaempferia parviflora Wall ex Baker (Zingiberaceae)
2.4.14 Pedalium murex L. (Pedaliaceae)
2.4.15 Panax ginseng (Araliaceae)
2.4.16 Tribulus terrestris L. (Zygophyllaceae)
2.4.17 Lepidium meyenii Walp. (Brassicaceae)
2.4.18 Zingiber officinale (Zingiberaceae Family)
2.4.19 Zosima absinthifolia (Apiaceae)
2.5 Prospects for the Future
2.6 Conclusion
References
3. Phytochemicals as Potential Inhibitors of Phosphodiesterase-5 for Management of Erectile Dysfunction
Anand Ganapathy A., Vijayakumari Mahadevan Hari Priya, Raman Krishnamoorthi and Alaganandam Kumaran
3.1 Introduction
3.2 Causes of ED
3.2.1 Psychogenic
3.2.2 Neurogenic
3.2.3 Endocrinological
3.2.4 Vasculogenic
3.2.5 Drug-Induced
3.3 Diagnosis of ED
3.4 Treatments for ED
3.4.1 Lifestyle Modification
3.4.2 Oral Therapy
3.4.3 Transurethral Therapies
3.4.4 Intracavernosal Therapies
3.4.5 Vacuum Erection Devices
3.4.6 Acupuncture and Complementary Medicine
3.5 PDE5 and ED
3.5.1 PDE5 and cGMP
3.5.2 Structure and Function of PDE5 Enzyme
3.5.3 Mechanism of PDE5 in ED Intervention
3.6 Phytochemicals as PDE5 Inhibitors
3.6.1 Alkaloids
3.6.2 Flavonoid
3.6.3 Others
3.7 Conclusion
References
4. Holistic Approaches to Benign Prostatic Hyperplasia: A Focus on Natural Therapies
Bharat Goel, Shivani Jaiswal and Tarkeshwar Dubey
4.1 Introduction
4.1.1 Pathophysiology of Benign Prostatic Hyperplasia
4.1.2 Treatment of Benign Prostatic Hyperplasia
4.2 Natural Products in Benign Prostatic Hyperplasia (BPH)
4.2.1 Flavonoids
4.2.2 Non-Flavonoid Polyphenols
4.2.3 Alkaloids
4.2.4 Triterpenoids
4.3 Plants Used in Benign Prostate Hyperplasia (BPH)
4.3.1 Saw Palmetto (S. repens, Sabal serrulata)
4.3.2 Rye Grass Pollen (Secale cereale)
4.3.3 African Cherry (Pygeum africanum)
4.3.4 Stinging Nettle (Urtica dioica)
4.3.5 African Potato (Hypoxis rooperi)
4.3.6 Field Pumpkin (Cucurbita pepo)
4.3.7 Tomato (Solanum lycopersicum)
4.3.8 Hairy Willow Herb (Epilobium parviflorum)
4.4 Conclusions
References
5. Unlocking Natural Arsenal for Prostate Cancer Care: From Garden to Clinic
Swati Arora, Sumit Sheoran, Samson Raj, Bhuvanesh Baniya, Neeraj Kumar, Anupam Kumar and Himanshu Singh
5.1 Introduction
5.2 Background of Prostate Cancer
5.3 Prostate Cancer: Main Risk Factors
5.3.1 Non-Modified Risk Factors
5.4 Therapeutic Strategies: A Brief Summary
5.5 Natural Arsenal and Prostate Cancer
5.6 Phytochemicals in Clinical Trials Against Prostate Cancer
5.7 Future Directions and Conclusion
References
6. Herbs as Antiandrogenic Agents
Pushpendra Kumar Khangar, Mayank Pandey, Nazneen Dubey and Aditya Ganeshpurkar
6.1 Introduction to Male Antifertility Agents
6.2 Mechanisms of Action
6.3 Plant-Derived Antiandrogenic Compounds
6.4 Pharmacological Studies and Clinical Trials
6.5 Commonly Studied Plant Species
6.6 Formulation and Delivery Methods
6.7 Regulatory Considerations
6.8 Potential Applications in Male Contraception
6.9 Safety and Side Effects
6.10 Future Directions in Research
6.11 Targeted Drug Delivery Systems
6.12 Challenges and Future Directions
6.13 Conclusion and Implications
References
7. Herbal Medicine for Prostatitis: A Current Approach
Satish Dubey, Harsh Yadav, Kundan Kumar Ojha, Shilpa Vinodia, Nagendra Singh Chauhan, Archana Markam, Sarita Chandrawanshi and Ashwini Kumar Dixit
Introduction
Pathophysiology of Prostatitis
Conventional Management of Prostatitis
Antibiotics
Alpha Blockers
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Role of Herbal Medicine in Prostatitis Management
Description of Some Key Medicinal Plants for Prostatitis
Serenoa repens Bartram J.K. Small (Saw Palmetto)
Curcuma Longa L. (Turmeric)
Plantago depressa Willd. (Ashvagola)
Challenges and Future Outlook
Conclusion
References
8. Natural Products Used in Male Pattern Baldness
Rishu Kumar, Gracy Nath, Gireesh Kumar Singh, Debapriya Garabadu, Narahari Narayan Palei, Priyanka Sharma and Bibhash Chandra Mohanta
8.1 Introduction
8.2 Forms of Baldness and Types of Male Pattern Baldness
8.3 Causes of Baldness and Molecular Mechanism
8.4 Treatment Approaches of Male Pattern Baldness
8.4.1 Male Pattern Baldness Treatment Approach: Drug Therapy
8.4.2 Surgical Method/Hair Transplantation
8.4.3 Limitation of Current and Other Therapy
8.4.4 Treatment through Natural Product
8.5 Natural Products in Male Pattern Baldness
8.5.1 Plant Based
8.5.1.1 Saw Palmetto (Serenoa repens)
8.5.1.2 Ginseng (Panax ginseng)
8.5.1.3 Aloe Vera (Aloe barbadensis miller)
8.5.1.4 Ginkgo Biloba
8.5.2 Herbal Extracts
8.5.2.1 Onion Extract (Allium cepa)
8.5.2.2 Green Tea (Camellia sinensis) Extract
8.5.2.3 Common Nettle Extract (Urtica dioica)
8.5.3 Essential Oils
8.5.3.1 Rosemary Oil (Rosmarinus officinalis)
8.5.3.2 Peppermint (Mentha piperita) Oil
8.5.3.3 Pumpkin Seed Oil (Cucurbita pepo)
8.5.4 Dietary Supplements
8.6 Future Perspective
8.7 Conclusion
References
9. Role of Plants and Herbal Products to Manage Male Fertility
Pratap Chand Mali, Prity Yadav, Neha Bharti and Suman Kumari
9.1 Introduction
9.2 Review of Literature
9.3 Discussion
9.4 Future Prospects
9.5 Acknowledgements
References
10. Plants Used as Androgenic
Neetu Kachhwaha
10.1 Introduction
10.2 Androgens and Phytoandrogens
10.2.1 Stilbene
10.2.2 Lignan
10.2.3 Coumesten
10.2.4 Isoflavones
10.3 Plants Having Androgenic Properties and Associated Diseases
10.3.1 Eurycoma longifolia
10.3.2 Lepidium meyenii (Maca)
10.3.3 Trigonella foenumgraecum
10.3.4 Tribulus terrestris
10.3.5 Withania somnifera
10.3.6 Panax ginseng
10.4 Mode of Action
10.4.1 Receptor Binding
10.4.2 Enzyme Inhibitor or Stimulation
10.4.3 Hormonal Pathway Modulation
10.4.4 Anti-Oxidant/Anti-Inflammatory Effects
10.4.5 Feedback Mechanism
10.5 Side Effects of Phytoandrogens
10.5.1 Gastrointestinal Disturbance
10.5.2 Hormonal Imbalance
10.5.3 Interaction with Other Medicines
10.5.4 Mood Swings
10.5.5 Prostate Problems
10.5.6 Allergic Reactions
10.5.7 Liver Impacts
10.6 Plant-Derived Anti-Androgens
10.7 Future Perspective
Conclusion
References
11. Natural Products Used in Parkinson’s Disease
Manish Kumar, Vipasha Mehta, Ankita Rangra and Shreya Chauhan
11.1 Introduction
11.2 Epidemiology
11.3 Causes of Parkinson’s Disease
11.3.1 Hereditary Factors
11.3.2 Age
11.3.3 Environmental Elements
11.3.4 Neuroinflammation
11.3.5 Oxidative Stress
11.3.6 Mitochondrial Dysfunction
11.4 Symptoms of PD
11.4.1 Motor Symptoms of Parkinson Disease
11.4.2 Non-Motor Symptoms of PD
11.5 Natural Product Used in PD
11.5.1 Neuroprotective Mechanisms of Ginger in PD
11.5.2 Neuroprotective Mechanisms of Mucuna Pruriens in Parkinson Disease
11.5.3 Neuroprotective Mechanisms of Green Tree in Parkinson Disease
11.5.4 Neuroprotective Mechanisms of Withania Somnifera in Parkinson Disease
11.5.5 Neuroprotective Mechanisms of Caffeine in Parkinson Disease
11.5.6 Neuroprotective Mechanisms of Ginkgolides and Bilobalides in Parkinson Disease
11.5.7 Neuroprotective Mechanisms of Cistanche Salsa in Parkinson Disease
11.5.8 Neuroprotective Mechanisms of Gastrodia Elata in Parkinson Disease
11.6 Conclusion
References
12. Stress Induced Male Infertility: Propitious Role of Herbal Drugs
Jai Malik, Komal Tyagi and Prachi Pranamya
12.1 Introduction
12.2 Various Causes of Male Infertility
12.2.1 Physical Reasons
12.2.2 Hormonal Defects
12.2.3 Genetic Factors
12.2.4 Lifestyle and Environment
12.2.5 Oxidative Stress (OS)
12.3 Some Common Plants Used to Treat Male Infertility
12.3.1 Panax ginseng (Araliaceae)
12.3.2 Withania somnifera (Solanaceae)
12.3.3 Mucuna pruriens (Fabaceae)
12.3.4 Asparagus racemosus (Asparagaceae/Lilliaceae)
12.3.5 Tribulus terrestris (Zygophyllaceae)
12.3.6 Allium sativum (Liliaceae)
12.3.7 Shilajit (Asphaltum, Mineral Pitch)
12.4 Conclusion
References
13. Natural Products as Spermatogenesis
Abhishek Mohanta, Sonalinandini Samanta, Sohini Chatterjee, Mousumi Tudu, Ahana Hazra, Arnab De and Amalesh Samanta
13.1 Introduction
13.2 Current Scenario
13.3 Lifestyle Effects on Spermatogenesis
13.3.1 Nutrition
13.3.2 Alcohol Consumption
13.3.3 Smoking
13.3.4 Obesity
13.3.5 Stress
13.3.6 Sleep
13.3.7 Environmental Exposure
13.4 Natural Plants Used in Spermatogenesis
13.5 Plants that Affect Sertoli Cells
13.5.1 Plant Extracts which Effect the Sertoli Cells and Enhance the Process of Spermatogenesis Includes
13.5.2 Effect of Plant Extracts on Leydig Cells and Steroidogenesis
13.5.3 There are Several Natural Plat Products that Affect the Functioning of Leydig Cells Including
13.5.4 Marketed Products Used in Various Sexual Disorders
13.6 Future Perspective
13.7 Conclusion
References
14. Potential Role of Fructans in Male Cancers
Javad Arabpour
14.1 Introduction
14.2 Chemical Aspect of Fructan and Derivatives
14.3 Bioactivity of Fructan
14.3.1 Introduction to Fructan as a Health-Promoting Ingredient
14.3.2 Prebiotic Effects of Fructan
14.3.3 Fructan and Lipid Metabolism
14.3.4 Antioxidant Properties of Fructan
14.3.5 Anticancer Potential of Fructan
14.4 Pharmaceutical Application of Fructans
14.4.1 Drug
14.4.1.1 Prebiotic Effects
14.4.1.2 Antioxidant
14.4.1.3 Anticancer
14.4.2 Delivery Methods
14.4.2.1 Inulin Hydrogels
14.4.2.2 Targeted Drug Delivery
14.4.3 Protein Stabilization
14.4.4 Solution Behavior Alteration
14.4.5 Synergist Properties
14.5 Fructans and Prostate Cancer
14.6 IV. Fructans and Other Male Cancers
14.6.1 Liver Cancer
14.6.2 Colorectal Cancer
14.6.3 Melanoma
14.7 Clinical Trials
14.8 Conclusions and Future Perspectives
References
Index
Back to Top
Preface
1. Natural Products for the Treatment of Testicular Cancer
Harpreet Singh, Himanshu Sharma, Rashmi Pathak, Amit Anand, Arvind Kumar, Amrita Mishra and Arun Kumar Mishra
1.1 Introduction
1.2 Promising Natural Products for Testicular Cancer
1.2.1 Plant-Derived Compounds
1.2.1.1 Alkaloids
1.2.1.2 Polyphenols
1.2.2 Marine-Derived Compounds
1.2.2.1 Marine Algae Compounds
1.2.2.2 Marine Invertebrate-Derived Compounds
1.2.3 Herbal Remedies from Traditional Medicine
1.2.3.1 Traditional Chinese Medicine
1.2.3.2 Ayurveda
1.2.3.3 Indigenous Healing Practices
1.3 Mechanisms of Action of Natural Products in Testicular Cancer
1.3.1 Induction of Apoptosis
1.3.2 Inhibition of Angiogenesis
1.3.3 Modulation of Signaling Pathways
1.3.4 Immune System Activation
1.3.5 Antioxidant and Anti-Inflammatory Effects
1.4 Preclinical Studies and In Vitro Evidence
1.4.1 Animal Models of Testicular Cancer
1.4.2 Cell Line Studies
1.4.3 Biochemical Assays and Molecular Investigations
1.4.4 Synergistic Effects of Conventional Treatments
1.5 Clinical Trials and Human Studies
1.5.1 Phase I, II, and III Clinical Trials
1.5.2 Safety and Efficacy of Natural Products
1.5.3 Patient Outcomes and Quality of Life
1.6 Role of Natural Products in Testicular Cancer
1.6.1 Emerging Natural Products for Testicular Cancer
1.6.2 Combination Therapies
1.6.3 Personalized Medicine Approaches
1.7 Future Prospects
1.8 Conclusion
References
2. Natural Products for the Treatment of Male Sexual Dysfunction
Subhiksha. S., Akash. J., B. Siva Kumar and K. Ilango
2.1 Introduction
2.2 Male Reproductive System
2.3 The Physiological Process of Achieving an Erection
2.4 Natural Substances that can Enhance Sexual Desire and Performance
2.4.1 Alpiniacalcarata Roscoe (Zingiberaceae)
2.4.2 Anacyclus pyrethrum DC (Asteraceae)
2.4.3 Asparagus racemosus (Liliaceae)
2.4.4 Allium sativum (Alliaceae)
2.4.5 Anethum graveolens L. (Apiaceae)
2.4.6 Butea frondosa Koenig ex Roxb. (Papilionaceae)
2.4.7 Blepharis (Acanthaceae)
2.4.8 Butea superba (Leguminosae)
2.4.9 Curculigo orchioides (Hypoxidaceae)
2.4.10 Durio zibenthinus (Bombacaceae)
2.4.11 Eurycoma longifolia jack (Simaroubaceae)
2.4.12 Glycyrrhiza glabra (Leguminoaceae)
2.4.13 Kaempferia parviflora Wall ex Baker (Zingiberaceae)
2.4.14 Pedalium murex L. (Pedaliaceae)
2.4.15 Panax ginseng (Araliaceae)
2.4.16 Tribulus terrestris L. (Zygophyllaceae)
2.4.17 Lepidium meyenii Walp. (Brassicaceae)
2.4.18 Zingiber officinale (Zingiberaceae Family)
2.4.19 Zosima absinthifolia (Apiaceae)
2.5 Prospects for the Future
2.6 Conclusion
References
3. Phytochemicals as Potential Inhibitors of Phosphodiesterase-5 for Management of Erectile Dysfunction
Anand Ganapathy A., Vijayakumari Mahadevan Hari Priya, Raman Krishnamoorthi and Alaganandam Kumaran
3.1 Introduction
3.2 Causes of ED
3.2.1 Psychogenic
3.2.2 Neurogenic
3.2.3 Endocrinological
3.2.4 Vasculogenic
3.2.5 Drug-Induced
3.3 Diagnosis of ED
3.4 Treatments for ED
3.4.1 Lifestyle Modification
3.4.2 Oral Therapy
3.4.3 Transurethral Therapies
3.4.4 Intracavernosal Therapies
3.4.5 Vacuum Erection Devices
3.4.6 Acupuncture and Complementary Medicine
3.5 PDE5 and ED
3.5.1 PDE5 and cGMP
3.5.2 Structure and Function of PDE5 Enzyme
3.5.3 Mechanism of PDE5 in ED Intervention
3.6 Phytochemicals as PDE5 Inhibitors
3.6.1 Alkaloids
3.6.2 Flavonoid
3.6.3 Others
3.7 Conclusion
References
4. Holistic Approaches to Benign Prostatic Hyperplasia: A Focus on Natural Therapies
Bharat Goel, Shivani Jaiswal and Tarkeshwar Dubey
4.1 Introduction
4.1.1 Pathophysiology of Benign Prostatic Hyperplasia
4.1.2 Treatment of Benign Prostatic Hyperplasia
4.2 Natural Products in Benign Prostatic Hyperplasia (BPH)
4.2.1 Flavonoids
4.2.2 Non-Flavonoid Polyphenols
4.2.3 Alkaloids
4.2.4 Triterpenoids
4.3 Plants Used in Benign Prostate Hyperplasia (BPH)
4.3.1 Saw Palmetto (S. repens, Sabal serrulata)
4.3.2 Rye Grass Pollen (Secale cereale)
4.3.3 African Cherry (Pygeum africanum)
4.3.4 Stinging Nettle (Urtica dioica)
4.3.5 African Potato (Hypoxis rooperi)
4.3.6 Field Pumpkin (Cucurbita pepo)
4.3.7 Tomato (Solanum lycopersicum)
4.3.8 Hairy Willow Herb (Epilobium parviflorum)
4.4 Conclusions
References
5. Unlocking Natural Arsenal for Prostate Cancer Care: From Garden to Clinic
Swati Arora, Sumit Sheoran, Samson Raj, Bhuvanesh Baniya, Neeraj Kumar, Anupam Kumar and Himanshu Singh
5.1 Introduction
5.2 Background of Prostate Cancer
5.3 Prostate Cancer: Main Risk Factors
5.3.1 Non-Modified Risk Factors
5.4 Therapeutic Strategies: A Brief Summary
5.5 Natural Arsenal and Prostate Cancer
5.6 Phytochemicals in Clinical Trials Against Prostate Cancer
5.7 Future Directions and Conclusion
References
6. Herbs as Antiandrogenic Agents
Pushpendra Kumar Khangar, Mayank Pandey, Nazneen Dubey and Aditya Ganeshpurkar
6.1 Introduction to Male Antifertility Agents
6.2 Mechanisms of Action
6.3 Plant-Derived Antiandrogenic Compounds
6.4 Pharmacological Studies and Clinical Trials
6.5 Commonly Studied Plant Species
6.6 Formulation and Delivery Methods
6.7 Regulatory Considerations
6.8 Potential Applications in Male Contraception
6.9 Safety and Side Effects
6.10 Future Directions in Research
6.11 Targeted Drug Delivery Systems
6.12 Challenges and Future Directions
6.13 Conclusion and Implications
References
7. Herbal Medicine for Prostatitis: A Current Approach
Satish Dubey, Harsh Yadav, Kundan Kumar Ojha, Shilpa Vinodia, Nagendra Singh Chauhan, Archana Markam, Sarita Chandrawanshi and Ashwini Kumar Dixit
Introduction
Pathophysiology of Prostatitis
Conventional Management of Prostatitis
Antibiotics
Alpha Blockers
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Role of Herbal Medicine in Prostatitis Management
Description of Some Key Medicinal Plants for Prostatitis
Serenoa repens Bartram J.K. Small (Saw Palmetto)
Curcuma Longa L. (Turmeric)
Plantago depressa Willd. (Ashvagola)
Challenges and Future Outlook
Conclusion
References
8. Natural Products Used in Male Pattern Baldness
Rishu Kumar, Gracy Nath, Gireesh Kumar Singh, Debapriya Garabadu, Narahari Narayan Palei, Priyanka Sharma and Bibhash Chandra Mohanta
8.1 Introduction
8.2 Forms of Baldness and Types of Male Pattern Baldness
8.3 Causes of Baldness and Molecular Mechanism
8.4 Treatment Approaches of Male Pattern Baldness
8.4.1 Male Pattern Baldness Treatment Approach: Drug Therapy
8.4.2 Surgical Method/Hair Transplantation
8.4.3 Limitation of Current and Other Therapy
8.4.4 Treatment through Natural Product
8.5 Natural Products in Male Pattern Baldness
8.5.1 Plant Based
8.5.1.1 Saw Palmetto (Serenoa repens)
8.5.1.2 Ginseng (Panax ginseng)
8.5.1.3 Aloe Vera (Aloe barbadensis miller)
8.5.1.4 Ginkgo Biloba
8.5.2 Herbal Extracts
8.5.2.1 Onion Extract (Allium cepa)
8.5.2.2 Green Tea (Camellia sinensis) Extract
8.5.2.3 Common Nettle Extract (Urtica dioica)
8.5.3 Essential Oils
8.5.3.1 Rosemary Oil (Rosmarinus officinalis)
8.5.3.2 Peppermint (Mentha piperita) Oil
8.5.3.3 Pumpkin Seed Oil (Cucurbita pepo)
8.5.4 Dietary Supplements
8.6 Future Perspective
8.7 Conclusion
References
9. Role of Plants and Herbal Products to Manage Male Fertility
Pratap Chand Mali, Prity Yadav, Neha Bharti and Suman Kumari
9.1 Introduction
9.2 Review of Literature
9.3 Discussion
9.4 Future Prospects
9.5 Acknowledgements
References
10. Plants Used as Androgenic
Neetu Kachhwaha
10.1 Introduction
10.2 Androgens and Phytoandrogens
10.2.1 Stilbene
10.2.2 Lignan
10.2.3 Coumesten
10.2.4 Isoflavones
10.3 Plants Having Androgenic Properties and Associated Diseases
10.3.1 Eurycoma longifolia
10.3.2 Lepidium meyenii (Maca)
10.3.3 Trigonella foenumgraecum
10.3.4 Tribulus terrestris
10.3.5 Withania somnifera
10.3.6 Panax ginseng
10.4 Mode of Action
10.4.1 Receptor Binding
10.4.2 Enzyme Inhibitor or Stimulation
10.4.3 Hormonal Pathway Modulation
10.4.4 Anti-Oxidant/Anti-Inflammatory Effects
10.4.5 Feedback Mechanism
10.5 Side Effects of Phytoandrogens
10.5.1 Gastrointestinal Disturbance
10.5.2 Hormonal Imbalance
10.5.3 Interaction with Other Medicines
10.5.4 Mood Swings
10.5.5 Prostate Problems
10.5.6 Allergic Reactions
10.5.7 Liver Impacts
10.6 Plant-Derived Anti-Androgens
10.7 Future Perspective
Conclusion
References
11. Natural Products Used in Parkinson’s Disease
Manish Kumar, Vipasha Mehta, Ankita Rangra and Shreya Chauhan
11.1 Introduction
11.2 Epidemiology
11.3 Causes of Parkinson’s Disease
11.3.1 Hereditary Factors
11.3.2 Age
11.3.3 Environmental Elements
11.3.4 Neuroinflammation
11.3.5 Oxidative Stress
11.3.6 Mitochondrial Dysfunction
11.4 Symptoms of PD
11.4.1 Motor Symptoms of Parkinson Disease
11.4.2 Non-Motor Symptoms of PD
11.5 Natural Product Used in PD
11.5.1 Neuroprotective Mechanisms of Ginger in PD
11.5.2 Neuroprotective Mechanisms of Mucuna Pruriens in Parkinson Disease
11.5.3 Neuroprotective Mechanisms of Green Tree in Parkinson Disease
11.5.4 Neuroprotective Mechanisms of Withania Somnifera in Parkinson Disease
11.5.5 Neuroprotective Mechanisms of Caffeine in Parkinson Disease
11.5.6 Neuroprotective Mechanisms of Ginkgolides and Bilobalides in Parkinson Disease
11.5.7 Neuroprotective Mechanisms of Cistanche Salsa in Parkinson Disease
11.5.8 Neuroprotective Mechanisms of Gastrodia Elata in Parkinson Disease
11.6 Conclusion
References
12. Stress Induced Male Infertility: Propitious Role of Herbal Drugs
Jai Malik, Komal Tyagi and Prachi Pranamya
12.1 Introduction
12.2 Various Causes of Male Infertility
12.2.1 Physical Reasons
12.2.2 Hormonal Defects
12.2.3 Genetic Factors
12.2.4 Lifestyle and Environment
12.2.5 Oxidative Stress (OS)
12.3 Some Common Plants Used to Treat Male Infertility
12.3.1 Panax ginseng (Araliaceae)
12.3.2 Withania somnifera (Solanaceae)
12.3.3 Mucuna pruriens (Fabaceae)
12.3.4 Asparagus racemosus (Asparagaceae/Lilliaceae)
12.3.5 Tribulus terrestris (Zygophyllaceae)
12.3.6 Allium sativum (Liliaceae)
12.3.7 Shilajit (Asphaltum, Mineral Pitch)
12.4 Conclusion
References
13. Natural Products as Spermatogenesis
Abhishek Mohanta, Sonalinandini Samanta, Sohini Chatterjee, Mousumi Tudu, Ahana Hazra, Arnab De and Amalesh Samanta
13.1 Introduction
13.2 Current Scenario
13.3 Lifestyle Effects on Spermatogenesis
13.3.1 Nutrition
13.3.2 Alcohol Consumption
13.3.3 Smoking
13.3.4 Obesity
13.3.5 Stress
13.3.6 Sleep
13.3.7 Environmental Exposure
13.4 Natural Plants Used in Spermatogenesis
13.5 Plants that Affect Sertoli Cells
13.5.1 Plant Extracts which Effect the Sertoli Cells and Enhance the Process of Spermatogenesis Includes
13.5.2 Effect of Plant Extracts on Leydig Cells and Steroidogenesis
13.5.3 There are Several Natural Plat Products that Affect the Functioning of Leydig Cells Including
13.5.4 Marketed Products Used in Various Sexual Disorders
13.6 Future Perspective
13.7 Conclusion
References
14. Potential Role of Fructans in Male Cancers
Javad Arabpour
14.1 Introduction
14.2 Chemical Aspect of Fructan and Derivatives
14.3 Bioactivity of Fructan
14.3.1 Introduction to Fructan as a Health-Promoting Ingredient
14.3.2 Prebiotic Effects of Fructan
14.3.3 Fructan and Lipid Metabolism
14.3.4 Antioxidant Properties of Fructan
14.3.5 Anticancer Potential of Fructan
14.4 Pharmaceutical Application of Fructans
14.4.1 Drug
14.4.1.1 Prebiotic Effects
14.4.1.2 Antioxidant
14.4.1.3 Anticancer
14.4.2 Delivery Methods
14.4.2.1 Inulin Hydrogels
14.4.2.2 Targeted Drug Delivery
14.4.3 Protein Stabilization
14.4.4 Solution Behavior Alteration
14.4.5 Synergist Properties
14.5 Fructans and Prostate Cancer
14.6 IV. Fructans and Other Male Cancers
14.6.1 Liver Cancer
14.6.2 Colorectal Cancer
14.6.3 Melanoma
14.7 Clinical Trials
14.8 Conclusions and Future Perspectives
References
Index
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