-
Browse Book Series
- Adhesion and Adhesives: Fundamental and Applied Aspects
- Advances in Additive Manufacturing Technologies
- Advances in Antenna, Microwave and Communication Engineering
- Advances in Biofeedstocks and Biofuels
- Advances in Cyber Security
- Advances in Data Engineering and Machine Learning
- Advances in E-Mobility
- Advances in Hydrogen Production and Storage
- Advances in Intelligent and Scientific Computing (AISC)
- Advances in Learning Analytics for Intelligent Cloud-IoT Systems
- Advances in Membrane Processes
- Advances in Nanotechnology and Applications
- Advances in Natural Gas Engineering
- Advances in Pipes and Pipelines
- Advances in Production Engineering
- Advances in Solar Cell Materials and Storage
- Applied Functional Materials
- Artificial Intelligence and Soft Computing for Industrial Transformation
- Astrobiology Perspectives on Life in the Universe
- Bioprocessing in Food Science
- Computational Intelligence and Biomedical Engineering
- Concise Introductions to AI and Data Science
- Cyber Systems and Quantum Engineering
- Decentralized Systems and Next-Generation Internet
- Diatoms: Biology and Applications
- Digital Convergence in Engineering Systems
- Emerging Trends in Medicinal and Pharmaceutical Chemistry
- Engineering Systems Design for Sustainable Development
- Fintech in a Sustainable Digital Society
- Industry 5.0 Transformation Applications
- Infectious and Rare Diseases
- Innovations in Materials and Manufacturing
- Machine Learning in Biomedical Science and Healthcare Informatics
- Materials Degradation and Failure
- Mathematics and Computer Science
- Next-Generation Computing and Communication Engineering
- Performability Engineering Series
- Rotating Machinery Fundamentals and Advances
- Studies in Computational Intelligence and Smart Technologies
- Sustainable Computing and Optimization
Browse Subject Areas
For Authors
Submit a ProposalBiomedical Materials and Diagnostic Devices
 | Edited by Ashutosh Tiwari, Murugan Ramalingam, Hisatoshi Kobayashi and Anthony P. F. Turner Copyright: 2012 | Status: Published ISBN: 9781118030141 | Hardcover | 640 pages Price: $220 USD  |
One Line Description
Biomedical Materials and Diagnostics Devices provides an up-to-date overview of the fascinating and emerging field of biomedical materials and devices, fabrication, performance and uses.
Audience
This book is intended to be suitable for a wide readership including university students and researchers from diverse backgrounds such as chemistry, materials science, physics, pharmacy, biological science and bio-medical engineering. It can be used not only as a text book for both undergraduate and graduate students, but also as a review and reference book for researchers in the materials science, bioengineering, pharmacy, biotechnology and nanotechnology.
This book is intended to be suitable for a wide readership including university students and researchers from diverse backgrounds such as chemistry, materials science, physics, pharmacy, biological science and bio-medical engineering. It can be used not only as a text book for both undergraduate and graduate students, but also as a review and reference book for researchers in the materials science, bioengineering, pharmacy, biotechnology and nanotechnology.
Description
The biomedical materials with the most promising potential combine biocompatibility with the ability to precisely adjust biological phenomenon in a controlled manner. The world market for biomedical and diagnostic devices is expanding rapidly and the pace of academic research resulted in about 50,000 published papers in 2011. It is timely, therefore, to assemble a volume on this important subject.
The chapters in the book seek to address progress in successful design strategies for biomedical materials and devices such as the use of collagen, crystalline calcium orthophosphates, amphiphilic polymers, polycaprolactone, biomimetic assembly, bio-nanocomposite matrices, bio-silica, theranostic nanobiomaterials, intelligent drug delivery systems, elastomeric nanobiomaterials, electrospun nano-matrices, metal nanoparticles and a variety of biosensors.
This large and comprehensive volume includes twenty chapters authored by some of the leading researchers and is divided into four main areas: biomedical materials; diagnostic devices; drug delivery and therapeutics; and tissue engineering and organ regeneration.
Back to Top
The biomedical materials with the most promising potential combine biocompatibility with the ability to precisely adjust biological phenomenon in a controlled manner. The world market for biomedical and diagnostic devices is expanding rapidly and the pace of academic research resulted in about 50,000 published papers in 2011. It is timely, therefore, to assemble a volume on this important subject.
The chapters in the book seek to address progress in successful design strategies for biomedical materials and devices such as the use of collagen, crystalline calcium orthophosphates, amphiphilic polymers, polycaprolactone, biomimetic assembly, bio-nanocomposite matrices, bio-silica, theranostic nanobiomaterials, intelligent drug delivery systems, elastomeric nanobiomaterials, electrospun nano-matrices, metal nanoparticles and a variety of biosensors.
This large and comprehensive volume includes twenty chapters authored by some of the leading researchers and is divided into four main areas: biomedical materials; diagnostic devices; drug delivery and therapeutics; and tissue engineering and organ regeneration.
Back to Top
Author / Editor Details
Ashutosh Tiwari is an Assistant Professor of nanobioelectronics at Biosensors and Bioelectronics Centre, IFM-Linkoping University, Editor-in-Chief of Advanced Materials Letters, a materials chemist and graduated from University of Allahabad, India. He has published more than 125 articles and patents as well as authoring/editing in the field of materials science and technology. Dr. Tiwari has been honored by the Innovation in Materials Science Award and Medal-2011 during the International Conference on Chemistry for Mankind: Innovative Ideas in Life Sciences.
Ashutosh Tiwari is an Assistant Professor of nanobioelectronics at Biosensors and Bioelectronics Centre, IFM-Linkoping University, Editor-in-Chief of Advanced Materials Letters, a materials chemist and graduated from University of Allahabad, India. He has published more than 125 articles and patents as well as authoring/editing in the field of materials science and technology. Dr. Tiwari has been honored by the Innovation in Materials Science Award and Medal-2011 during the International Conference on Chemistry for Mankind: Innovative Ideas in Life Sciences.
Murugan Ramalingam is an associate professor of Biomaterials and Tissue Engineering at the Institut National de la Santé et de la Recherche Médicale U977, Faculté de Chirurgie Dentaire, Université de Strasbourg (UdS), France. Concurrently he holds an Adjunct Associate Professorship at the Tohoku University, Japan.
Hisatoshi Kobayashi is group leader of Biofunctional Materials at Biomaterials Centre, National Institute for Materials Science, Japan. He has published more than 150 publications, books and patents in the field of biomaterials science and technology as well as edited/authored three books on the advanced state-of-the-art of biomaterials.
Anthony P.F. Turner is currently Head of Division IFM-Linkoping University's new Centre for Biosensors and Bioelectronics. His previous thirty-five year academic career in the UK culminated in the positions of Principal (Rector) of Cranfield University and Distinguished Professor of Biotechnology. Professor Turner has more than 600 publications and patents in the field of biosensors and biomimetic sensors and is best known for his role in the development of glucose sensors for home-use by people with diabetes. He published the first textbook on Biosensors in 1987 and is Editor-In-Chief of the principal journal in his field, Biosensors & Bioelectronics, which he co-founded in 1985.
Back to Top
Table of Contents
Preface. Part I: Biomedical Materials. 1. Application of the Collagen as Biomaterials: Kwangwoo Nam and Akio Kishida. 1.1 Introduction. 1.2 Structural Aspect of Native Tissue. 1.2.1 Microenvironment. 1.2.2 Decellularization. 1.2.3 Strategy for Designing Collagen-based Biomaterials. 1.3 Processing of Collagen Matrix. 1.3.1 Fibrillogenesis. 1.3.2 Orientation. 1.3.3 Complex Formation and Blending. 1.3.4 Layered Structure. 1.4 Conclusions and Future Perspectives. References. 2. Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates: Sergey V. Dorozhkin. 2.1 Introduction. 2.2 General Information on Nano --. 2.3 Micron- and Submicron-Sized Calcium Orthophosphates versus the Nanodimensional Ones. 2.4 Nanodimensional and Nanocrystalline Calcium Orthophosphates in Calcified Tissues of Mammals. 2.4.1 Bones. 2.4.2 Teeth. 2.5 The Structure of the Nanodimensional and Nanocrystalline Apatites. 2.6 Synthesis of the Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.6.1 General Nanotechnological Approaches. 2.6.2 Nanodimensional and Nanocrystalline Apatites. 2.6.3 Nanodimensional and Nanocrystalline TCP. 2.6.4 Other Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.6.5 Biomimetic Construction Using Nanodimensional Particles. 2.7 Biomedical Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.7.1 Bone Repair. 2.7.2 Nanodimensional and Nanocrystalline Calcium Orthophosphates and Bone-related Cells. 2.7.3 Dental Applications. 2.7.4 Other Applications. 2.8 Other Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.9 Summary and Perspectives. 2.10 Conclusions. Closing Remarks. References and Notes. 3. Layer-by-Layer (LbL) Thin Film: From Conventional To Advanced Biomedical and Bioanalytical Applications: Wing Cheung Mak. 3.1 State-of-the-art LbL Technology. 3.2 Principle of Biomaterials Based Lbl Architecture. 3.3 LbL Thin Film for Biomaterials and Biomedical Implantations. 3.4 LbL Thin Film for Biosensors and Bioassays. 3.5 LbL Thin Film Architecture on Colloidal Materials. 3.6 LbL Thin Film for Drug Encapsulation and Delivery. 3.7 LbL Thin Film Based Micro/Nanoreactor. References. 4. Polycaprolactone based Nanobiomaterials: Narendra K. Singh and Pralay Maiti. 4.1 Introduction . 4.2 Preparation of Polycaprolactone Nanocomposites. 4.2.1 Solution Casting Method. 4.2.2 Melt Extrusion Technique. 4.2.3 In Situ Polymerization. 4.3 Characterization of Poly(caprolactone) Nanocomposites. 4.3.1 Nanostructure. 4.3.2 Microstructure. 4.4 Properties. 4.4.1 Mechanical Properties. 4.4.2 Thermal Properties. 4.4.3 Biodegradation. 4.5 Biocompatibility and Drug Delivery Application. 4.6 Conclusion. Acknowledgement. References. 5. Bone Substitute Materials in Trauma and Orthopedic Surgery --Properties and Use in Clinic: Esther M.M. Van Lieshout. 5.1 Introduction. 5.2 Types of Bone Grafts. 5.2.1 Autologous Transplantation. 5.2.2 Allotransplantation and Xenotransplantation. 5.2.3 Alternative Bone Substitute Materials for Grafting. 5.3 Bone Substitute Materials. 5.3.1 General Considerations. 5.3.2 Calcium Phosphates. 5.3.3 Calcium Sulphates. 5.3.4 Bioactive Glass. 5.3.5 Miscellaneous Products. 5.3.6 Future Directions. 5.4 Combinations with Osteogenic and Osteoinductive Materials. 5.4.1 Osteogenic Substances. 5.4.2 Osteoinductive Substances. 5.5 Discussion and Conclusion. References. 6. Surface Functionalized Hydrogel Nanoparticles: Mehrdad Hamidi, Hajar Ashrafi and Amir Azadi. 6.1 Hydrogel Nanoparticles. 6.2 Hydrogel Nanoparticles Based on Chitosan. 6.3 Hydrogel Nanoparticles Based on Alginate. 6.4 Hydrogel Nanoparticles Based on Poly(vinyl Alcohol). 6.5 Hydrogel Nanoparticles Based on Poly(ethylene Oxide) and Poly(ethyleneimine). 6.6 Hydrogel Nanoparticles Based on Poly(vinyl Pyrrolidone). 6.7 Hydrogel Nanoparticles Based on Poly-N-Isopropylacrylamide. 6.8 Smart Hydrogel Nanoparticles. 6.9 Self-assembled Hydrogel Nanoparticles. 6.10 Surface functionalization. 6.11 Surface Functionalized Hydrogel Nanoparticles. References. Part II: Diagnostic Devices. 7. Utility and Potential Application of Nanomaterials in Medicine: Ravindra P. Singh, Jeong -Woo Choi, Ashutosh Tiwari and Avinash Chand Pandey. 7.1 Introduction. 7.2 Nanoparticle Coatings. 7.3 Cyclic Peptides. 7.4 Dendrimers. 7.5 Fullerenes/Carbon Nanotubes/Graphene. 7.6 Functional Drug Carriers. 7.7 MRI Scanning Nanoparticles. 7.8 Nanoemulsions. 7.9 Nanofibers. 7.10 Nanoshells. 7.11 Quantum Dots. 7.12 Nanoimaging. 7.13 Inorganic Nanoparticles. 7.14 Conclusion. Acknowledgement. References. 8. Gold Nanoparticle-based Electrochemical Biosensors for Medical Applications: Å"lk Anik. 8.1 Introduction. 8.2 Electrochemical Biosensors. 8.2.1 Gold Nanoparticles. 8.3 Conclusion. References. 9. Impedimetric DNA Sensing Employing Nanomaterials: Manel del Valle and Alessandra Bonanni. 9.1 Introduction. 9.1.1 DNA Biosensors (Genosensors). 9.1.2 Electrochemical Genosensors. 9.2 Electrochemical Impedance Spectroscopy for Genosensing. 9.2.1 Theoretical Background. 9.2.2 Impedimetric Genosensors. 9.3 Nanostructured Carbon Used in Impedimetric Genosensors. 9.3.1 Carbon Nanotubes and Nanostructured Diamond. 9.3.2 Graphene-based Platforms. 9.4 Nanostructured Gold Used in Impedimetric Genosensors. 9.4.1 Gold Nanoelectrodes. 9.4.2 Gold Nanoparticles Used as Labels. 9.5 Quantum Dots for Impedimetric Genosensing. 9.6 Impedimetric Genosensors for Point-of-Care Diagnosis. 9.7 Conclusions (Past, Present and Future Perspectives). Acknowledgements. References. 10. Bionanocomposite Matrices in Electrochemical Biosensors: Ashutosh Tiwari, Atul Tiwari and Ravindra P. Singh. 10.1 Introduction. 10.2 Fabrication of SiO2-CHIT/CNTs Bionanocomposites. 10.3 Preparation of Bioelectrodes. 10.4 Characterizations. 10.5 Electrocatalytic Properties. 10.6 Photometric Response. 10.7 Conclusions. Acknowledgements. References. 11. Biosilica --Nanocomposites - Nanobiomaterials for Biomedical Engineering and Sensing Applications: Nikos Chaniotakis and Raluca Buiculescu. 11.1 Introduction. 11.2 Silica Polymerization Process. 11.3 Biocatalytic Formation of Silica. 11.4 Biosilica Nanotechnology. 11.5 Applications. 11.5.1 Photonic Materials. 11.5.2 Enzyme Stabilization. 11.5.3 Biosensor Development. 11.5.4 Surface Modification for Medical Applications. 11.6 Conclusions. References. 12. Molecularly Imprinted Nanomaterial-based Highly Sensitive and Selective Medical Devices: Bhim Bali Prasad and Mahavir Prasad Tiwari. 12.1 Introduction. 12.2 Molecular Imprinted Polymer Technology. 12.2.1 Introduction of Molecular Recognition. 12.2.2 Molecular Imprinting Polymerization: Background. 12.2.3 Contributions of Polyakov, Pauling and Dickey. 12.2.4 Approaches Toward Synthesis of MIPs. 12.2.5 Optimization of the Polymer Structure. 12.2.3 Molecularly Imprinted Nanomaterials. 12.4 Molecularly Imprinted Nanomaterial-based Sensing Devices. 12.4.1 Electrochemical Sensors. 12.4.2 Optical Sensors. 12.4.3 Mass Sensitive Devices. 12.5 Conclusion. References. Part III: Drug Delivery and Therapeutics. 13. Ground-Breaking Changes in Mimetic and Novel Nanostructured Composites for Intelligent-, Adaptive- and In vivo-responsive Drug Delivery Therapies: Dipak K. Sarker. 13. 1 Introduction. 13.1.1 Diseases of Major Importance in Society. 13.1.2 Types of Cancers and Diseases Requiring Specific Dosage Delivery. 13.2 Obstacles to the Clinician. 13.3 Hurdles for the Pharmaceuticist. 13.4 Nanostructures. 13.4.1 Key Current Know-how. 13.5 Surface Coating. 13.6 Cell Promoting, Toxicity and Clearance. 13.7 Formulation Conditions and Parameters. 13.8 Delivery Systems. 13.8.1 State-of-the-Art Technological Innovation. 13.9 Evaluation. 13.9.1 Future Scientific Direction. 13.10 Conclusions. References. 14. Progress of Nanobiomaterials for Theranostic Systems: Dipendra Gyawali, Michael Palmer, Richard T. Tran and Jian Yang. 14.1 Introduction. 14.1.1 Nanomaterials and Nanomedicine. 14.1.2 Drug Delivery, Imaging, and Targeting. 14.1.3 Theranostic Nanomedicine. 14.2 Design Concerns for Theranostic Nanosystems. 14.2.1 Size and Stability. 14.2.2 Surface Area and Chemistry. 14.2.3 Drug Loading and Release. 14.2.4 Imaging. 14.2.5 Targeting. 14.3 Designing a Smart and Functional Theranostic System. 14.3.1 Tailoring Size and Shape of the Particles. 14.3.2 Degradation and Drug Release Kinetics. 14.3.3 Surface Properties and Placement of Targeting Molecules. 14.4 Materials for Theranostic System. 14.4.1 Polymeric Systems. 14.4.2 Diagnostic and Imaging Materials. 14.5 Theranostic Systems and Applications. 14.5.1 Polymeric Nanoparticle-based Theranostic System. 14.5.2 QD-based Theranostic System. 14.5.3 Colloidal Gold-particle-based Theranostic System. 14.5.4 Iron-oxide-based Theranostic Systems. 14.6 Future Outlook. References. 15. Intelligent Drug Delivery Systems for Cancer Therapy: Mousa Jafari, Bahram Zargar, M. Soltani, D. Nedra Karunaratne, Brian Ingalls and P. Chen. 15.1 Introduction. 15.2 Peptides for Nucleic Acid and Drug Delivery in Cancer Therapy. 15.2.1 Self-assembling Peptides as Carriers for Anticancer Drugs. 15.2.2 Different Classes of Peptides Used in Gene Delivery. 15.2.3 Protein-derived and Designed CPPs. 15.2.4 Cell Targeting Peptides. 15.2.5 Nuclear Localization Peptides. 15.3 Lipid Carriers. 15.3.1 Liposomes. 15.3.2 Modified Liposomes. 15.3.3 Targeted Lipid Carriers. 15.3.4 Bolaamphiphiles. 15.3.5 Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs). 15.3.6 MixedSystems. 15.4 Polymeric Carriers. 15.4.1 Polymeric Nanoparticles. 15.4.2 Dendrimers. 15.4.3 Polymer-Protein/Aptamer Conjugates. 15.4.4 Polymer-Drug Conjugates. 15.4.5 Noncovalent Drug Conjugates. 15.4.6 Cationic Polymers. 15.4.7 Polymers for Triggered Drug Release. 15.4.8 Polymerosomes. 15.4.9 Other Applications. 15.5 Bactria-Mediated Cancer Therapy. 15.5.1 The Tumor Microenvironment. 15.5.2 Salmonella-mediated Cancer Therapy. 15.5.3 Clostridium-mediated Cancer Therapy. 15.6 Conclusion. References. Part IV: Tissue Engineering and Organ Regeneration. 16. The Evolution of Abdominal Wall Reconstruction and the Role of Nanobiotecnology in the Development of Intelligent Abdominal Wall Mesh: Cherif Boutros, Hany F. Sobhi and Nader Hanna. 16.1 The Complex Structure of the Abdominal Wall. 16.2 Need for Abdominal Wall Reconstruction. 16.3 Failure of Primary Repair. 16.4 Limitations of the Synthetic Meshes. 16.5 Introduction of Biomaterials To Overcome Synthetic Mesh Limitations. 16.6 Ideal Material for Abdominal Wall Reconstruction. 16.7 Role of Bionanotechnology in Providing the Ideal Material. 16.8 Future Directions. References. >B>17. Poly(Polyol Sebacate)-based Elastomeric Nanobiomaterials for Soft Tissue Engineering: Qizhi Chen. 17.1 Introduction. 17.2 Poly(polyol sebacate) Elastomers. 17.2.1 Synthesis and Processing of Poly(polyol sebacate). 17.2.2 Biocompatibility of PPS. 17.2.3 Biodegradation of PPS. 17.2.4 Mechanical Properties of PPS. 17.2.5 Applications of PPS in Tissue Engineering. 17.2.6 Poly(polyol sebacate)-based Copolymers. 17.2.7 Summary of PPS. 17.3 Elastomeric Nanocomposites. 17.3.1 Introduction to Elastomeric Nanocomposites. 17.3.2 Thermoplastic Rubber-based Nanocomposites. 17.3.3 Crosslinked Elastomer-based Nanocomposites. 17.4 Summary. References. 18. Electrospun Nanomatrix for Tissue Regeneration: Debasish Mondal and Ashutosh Tiwari. 18.1 Introduction. 18.2 Electrospun Nanomatrix. 18.3 Polymeric Nanomatrices for Tissue Engineering. 18.3.1 Natural Polymers. 18.3.2 Synthetic Polymers. 18.4 Biocompatibility of the Nanomatrix. 18.5 Electrospun Nanomatrices for Tissue Engineering. 18.5.1 Bone Tissue Engineering. 18.5.2 Cartilage Tissue Engineering. 18.5.3 Ligament Tissue Engineering. 18.5.4 Skeletal Muscle Tissue Engineering. 18.5.5 Skin Tissue Engineering. 18.5.6 Vascular Tissue Engineering. 18.5.7 Nerve Tissue Engineering. 18.6 Status and Prognosis. References. 19. Conducting Polymer Composites for Tissue Engineering Scaffolds: Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi. 19.1 Introduction. 19.2 Conducting Polymers. 19.3 Synthesis of Conducting Polymers. 19.4 Application of Conducting Polymer in Tissue Engineering. 19.5 Polypyrrole. 19.6 Poly(3,4-ethylene dioxythiophene). 19.7 Polyaniline. 19.8 Carbon Nanotube. 19.9 Future Prospects and Conclusions. Acknowledgements. References. 20. Cell Patterning Technologies for Tissue Engineering: Azadeh Seidi and Murugan Ramalingam. 20.1 Introduction. 20.2 Patterned Co-culture Techniques. 20.2.1 Substrate Patterning with ECM Components. 20.2.2 Microfluidic-based Patterning. 20.2.3 Switchable Surface-based Patterning. 20.2.4 Mechanical and Stencil-based Patterning. 20.2.5 3D Patterned Co-cultures. 20.3 Applications of Co-cultures in Tissue Engineering. 20.4 Concluding Remarks. Acknowledgements. References. Index.
Back to Top
Preface. Part I: Biomedical Materials. 1. Application of the Collagen as Biomaterials: Kwangwoo Nam and Akio Kishida. 1.1 Introduction. 1.2 Structural Aspect of Native Tissue. 1.2.1 Microenvironment. 1.2.2 Decellularization. 1.2.3 Strategy for Designing Collagen-based Biomaterials. 1.3 Processing of Collagen Matrix. 1.3.1 Fibrillogenesis. 1.3.2 Orientation. 1.3.3 Complex Formation and Blending. 1.3.4 Layered Structure. 1.4 Conclusions and Future Perspectives. References. 2. Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates: Sergey V. Dorozhkin. 2.1 Introduction. 2.2 General Information on Nano --. 2.3 Micron- and Submicron-Sized Calcium Orthophosphates versus the Nanodimensional Ones. 2.4 Nanodimensional and Nanocrystalline Calcium Orthophosphates in Calcified Tissues of Mammals. 2.4.1 Bones. 2.4.2 Teeth. 2.5 The Structure of the Nanodimensional and Nanocrystalline Apatites. 2.6 Synthesis of the Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.6.1 General Nanotechnological Approaches. 2.6.2 Nanodimensional and Nanocrystalline Apatites. 2.6.3 Nanodimensional and Nanocrystalline TCP. 2.6.4 Other Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.6.5 Biomimetic Construction Using Nanodimensional Particles. 2.7 Biomedical Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.7.1 Bone Repair. 2.7.2 Nanodimensional and Nanocrystalline Calcium Orthophosphates and Bone-related Cells. 2.7.3 Dental Applications. 2.7.4 Other Applications. 2.8 Other Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates. 2.9 Summary and Perspectives. 2.10 Conclusions. Closing Remarks. References and Notes. 3. Layer-by-Layer (LbL) Thin Film: From Conventional To Advanced Biomedical and Bioanalytical Applications: Wing Cheung Mak. 3.1 State-of-the-art LbL Technology. 3.2 Principle of Biomaterials Based Lbl Architecture. 3.3 LbL Thin Film for Biomaterials and Biomedical Implantations. 3.4 LbL Thin Film for Biosensors and Bioassays. 3.5 LbL Thin Film Architecture on Colloidal Materials. 3.6 LbL Thin Film for Drug Encapsulation and Delivery. 3.7 LbL Thin Film Based Micro/Nanoreactor. References. 4. Polycaprolactone based Nanobiomaterials: Narendra K. Singh and Pralay Maiti. 4.1 Introduction . 4.2 Preparation of Polycaprolactone Nanocomposites. 4.2.1 Solution Casting Method. 4.2.2 Melt Extrusion Technique. 4.2.3 In Situ Polymerization. 4.3 Characterization of Poly(caprolactone) Nanocomposites. 4.3.1 Nanostructure. 4.3.2 Microstructure. 4.4 Properties. 4.4.1 Mechanical Properties. 4.4.2 Thermal Properties. 4.4.3 Biodegradation. 4.5 Biocompatibility and Drug Delivery Application. 4.6 Conclusion. Acknowledgement. References. 5. Bone Substitute Materials in Trauma and Orthopedic Surgery --Properties and Use in Clinic: Esther M.M. Van Lieshout. 5.1 Introduction. 5.2 Types of Bone Grafts. 5.2.1 Autologous Transplantation. 5.2.2 Allotransplantation and Xenotransplantation. 5.2.3 Alternative Bone Substitute Materials for Grafting. 5.3 Bone Substitute Materials. 5.3.1 General Considerations. 5.3.2 Calcium Phosphates. 5.3.3 Calcium Sulphates. 5.3.4 Bioactive Glass. 5.3.5 Miscellaneous Products. 5.3.6 Future Directions. 5.4 Combinations with Osteogenic and Osteoinductive Materials. 5.4.1 Osteogenic Substances. 5.4.2 Osteoinductive Substances. 5.5 Discussion and Conclusion. References. 6. Surface Functionalized Hydrogel Nanoparticles: Mehrdad Hamidi, Hajar Ashrafi and Amir Azadi. 6.1 Hydrogel Nanoparticles. 6.2 Hydrogel Nanoparticles Based on Chitosan. 6.3 Hydrogel Nanoparticles Based on Alginate. 6.4 Hydrogel Nanoparticles Based on Poly(vinyl Alcohol). 6.5 Hydrogel Nanoparticles Based on Poly(ethylene Oxide) and Poly(ethyleneimine). 6.6 Hydrogel Nanoparticles Based on Poly(vinyl Pyrrolidone). 6.7 Hydrogel Nanoparticles Based on Poly-N-Isopropylacrylamide. 6.8 Smart Hydrogel Nanoparticles. 6.9 Self-assembled Hydrogel Nanoparticles. 6.10 Surface functionalization. 6.11 Surface Functionalized Hydrogel Nanoparticles. References. Part II: Diagnostic Devices. 7. Utility and Potential Application of Nanomaterials in Medicine: Ravindra P. Singh, Jeong -Woo Choi, Ashutosh Tiwari and Avinash Chand Pandey. 7.1 Introduction. 7.2 Nanoparticle Coatings. 7.3 Cyclic Peptides. 7.4 Dendrimers. 7.5 Fullerenes/Carbon Nanotubes/Graphene. 7.6 Functional Drug Carriers. 7.7 MRI Scanning Nanoparticles. 7.8 Nanoemulsions. 7.9 Nanofibers. 7.10 Nanoshells. 7.11 Quantum Dots. 7.12 Nanoimaging. 7.13 Inorganic Nanoparticles. 7.14 Conclusion. Acknowledgement. References. 8. Gold Nanoparticle-based Electrochemical Biosensors for Medical Applications: Å"lk Anik. 8.1 Introduction. 8.2 Electrochemical Biosensors. 8.2.1 Gold Nanoparticles. 8.3 Conclusion. References. 9. Impedimetric DNA Sensing Employing Nanomaterials: Manel del Valle and Alessandra Bonanni. 9.1 Introduction. 9.1.1 DNA Biosensors (Genosensors). 9.1.2 Electrochemical Genosensors. 9.2 Electrochemical Impedance Spectroscopy for Genosensing. 9.2.1 Theoretical Background. 9.2.2 Impedimetric Genosensors. 9.3 Nanostructured Carbon Used in Impedimetric Genosensors. 9.3.1 Carbon Nanotubes and Nanostructured Diamond. 9.3.2 Graphene-based Platforms. 9.4 Nanostructured Gold Used in Impedimetric Genosensors. 9.4.1 Gold Nanoelectrodes. 9.4.2 Gold Nanoparticles Used as Labels. 9.5 Quantum Dots for Impedimetric Genosensing. 9.6 Impedimetric Genosensors for Point-of-Care Diagnosis. 9.7 Conclusions (Past, Present and Future Perspectives). Acknowledgements. References. 10. Bionanocomposite Matrices in Electrochemical Biosensors: Ashutosh Tiwari, Atul Tiwari and Ravindra P. Singh. 10.1 Introduction. 10.2 Fabrication of SiO2-CHIT/CNTs Bionanocomposites. 10.3 Preparation of Bioelectrodes. 10.4 Characterizations. 10.5 Electrocatalytic Properties. 10.6 Photometric Response. 10.7 Conclusions. Acknowledgements. References. 11. Biosilica --Nanocomposites - Nanobiomaterials for Biomedical Engineering and Sensing Applications: Nikos Chaniotakis and Raluca Buiculescu. 11.1 Introduction. 11.2 Silica Polymerization Process. 11.3 Biocatalytic Formation of Silica. 11.4 Biosilica Nanotechnology. 11.5 Applications. 11.5.1 Photonic Materials. 11.5.2 Enzyme Stabilization. 11.5.3 Biosensor Development. 11.5.4 Surface Modification for Medical Applications. 11.6 Conclusions. References. 12. Molecularly Imprinted Nanomaterial-based Highly Sensitive and Selective Medical Devices: Bhim Bali Prasad and Mahavir Prasad Tiwari. 12.1 Introduction. 12.2 Molecular Imprinted Polymer Technology. 12.2.1 Introduction of Molecular Recognition. 12.2.2 Molecular Imprinting Polymerization: Background. 12.2.3 Contributions of Polyakov, Pauling and Dickey. 12.2.4 Approaches Toward Synthesis of MIPs. 12.2.5 Optimization of the Polymer Structure. 12.2.3 Molecularly Imprinted Nanomaterials. 12.4 Molecularly Imprinted Nanomaterial-based Sensing Devices. 12.4.1 Electrochemical Sensors. 12.4.2 Optical Sensors. 12.4.3 Mass Sensitive Devices. 12.5 Conclusion. References. Part III: Drug Delivery and Therapeutics. 13. Ground-Breaking Changes in Mimetic and Novel Nanostructured Composites for Intelligent-, Adaptive- and In vivo-responsive Drug Delivery Therapies: Dipak K. Sarker. 13. 1 Introduction. 13.1.1 Diseases of Major Importance in Society. 13.1.2 Types of Cancers and Diseases Requiring Specific Dosage Delivery. 13.2 Obstacles to the Clinician. 13.3 Hurdles for the Pharmaceuticist. 13.4 Nanostructures. 13.4.1 Key Current Know-how. 13.5 Surface Coating. 13.6 Cell Promoting, Toxicity and Clearance. 13.7 Formulation Conditions and Parameters. 13.8 Delivery Systems. 13.8.1 State-of-the-Art Technological Innovation. 13.9 Evaluation. 13.9.1 Future Scientific Direction. 13.10 Conclusions. References. 14. Progress of Nanobiomaterials for Theranostic Systems: Dipendra Gyawali, Michael Palmer, Richard T. Tran and Jian Yang. 14.1 Introduction. 14.1.1 Nanomaterials and Nanomedicine. 14.1.2 Drug Delivery, Imaging, and Targeting. 14.1.3 Theranostic Nanomedicine. 14.2 Design Concerns for Theranostic Nanosystems. 14.2.1 Size and Stability. 14.2.2 Surface Area and Chemistry. 14.2.3 Drug Loading and Release. 14.2.4 Imaging. 14.2.5 Targeting. 14.3 Designing a Smart and Functional Theranostic System. 14.3.1 Tailoring Size and Shape of the Particles. 14.3.2 Degradation and Drug Release Kinetics. 14.3.3 Surface Properties and Placement of Targeting Molecules. 14.4 Materials for Theranostic System. 14.4.1 Polymeric Systems. 14.4.2 Diagnostic and Imaging Materials. 14.5 Theranostic Systems and Applications. 14.5.1 Polymeric Nanoparticle-based Theranostic System. 14.5.2 QD-based Theranostic System. 14.5.3 Colloidal Gold-particle-based Theranostic System. 14.5.4 Iron-oxide-based Theranostic Systems. 14.6 Future Outlook. References. 15. Intelligent Drug Delivery Systems for Cancer Therapy: Mousa Jafari, Bahram Zargar, M. Soltani, D. Nedra Karunaratne, Brian Ingalls and P. Chen. 15.1 Introduction. 15.2 Peptides for Nucleic Acid and Drug Delivery in Cancer Therapy. 15.2.1 Self-assembling Peptides as Carriers for Anticancer Drugs. 15.2.2 Different Classes of Peptides Used in Gene Delivery. 15.2.3 Protein-derived and Designed CPPs. 15.2.4 Cell Targeting Peptides. 15.2.5 Nuclear Localization Peptides. 15.3 Lipid Carriers. 15.3.1 Liposomes. 15.3.2 Modified Liposomes. 15.3.3 Targeted Lipid Carriers. 15.3.4 Bolaamphiphiles. 15.3.5 Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs). 15.3.6 MixedSystems. 15.4 Polymeric Carriers. 15.4.1 Polymeric Nanoparticles. 15.4.2 Dendrimers. 15.4.3 Polymer-Protein/Aptamer Conjugates. 15.4.4 Polymer-Drug Conjugates. 15.4.5 Noncovalent Drug Conjugates. 15.4.6 Cationic Polymers. 15.4.7 Polymers for Triggered Drug Release. 15.4.8 Polymerosomes. 15.4.9 Other Applications. 15.5 Bactria-Mediated Cancer Therapy. 15.5.1 The Tumor Microenvironment. 15.5.2 Salmonella-mediated Cancer Therapy. 15.5.3 Clostridium-mediated Cancer Therapy. 15.6 Conclusion. References. Part IV: Tissue Engineering and Organ Regeneration. 16. The Evolution of Abdominal Wall Reconstruction and the Role of Nanobiotecnology in the Development of Intelligent Abdominal Wall Mesh: Cherif Boutros, Hany F. Sobhi and Nader Hanna. 16.1 The Complex Structure of the Abdominal Wall. 16.2 Need for Abdominal Wall Reconstruction. 16.3 Failure of Primary Repair. 16.4 Limitations of the Synthetic Meshes. 16.5 Introduction of Biomaterials To Overcome Synthetic Mesh Limitations. 16.6 Ideal Material for Abdominal Wall Reconstruction. 16.7 Role of Bionanotechnology in Providing the Ideal Material. 16.8 Future Directions. References. >B>17. Poly(Polyol Sebacate)-based Elastomeric Nanobiomaterials for Soft Tissue Engineering: Qizhi Chen. 17.1 Introduction. 17.2 Poly(polyol sebacate) Elastomers. 17.2.1 Synthesis and Processing of Poly(polyol sebacate). 17.2.2 Biocompatibility of PPS. 17.2.3 Biodegradation of PPS. 17.2.4 Mechanical Properties of PPS. 17.2.5 Applications of PPS in Tissue Engineering. 17.2.6 Poly(polyol sebacate)-based Copolymers. 17.2.7 Summary of PPS. 17.3 Elastomeric Nanocomposites. 17.3.1 Introduction to Elastomeric Nanocomposites. 17.3.2 Thermoplastic Rubber-based Nanocomposites. 17.3.3 Crosslinked Elastomer-based Nanocomposites. 17.4 Summary. References. 18. Electrospun Nanomatrix for Tissue Regeneration: Debasish Mondal and Ashutosh Tiwari. 18.1 Introduction. 18.2 Electrospun Nanomatrix. 18.3 Polymeric Nanomatrices for Tissue Engineering. 18.3.1 Natural Polymers. 18.3.2 Synthetic Polymers. 18.4 Biocompatibility of the Nanomatrix. 18.5 Electrospun Nanomatrices for Tissue Engineering. 18.5.1 Bone Tissue Engineering. 18.5.2 Cartilage Tissue Engineering. 18.5.3 Ligament Tissue Engineering. 18.5.4 Skeletal Muscle Tissue Engineering. 18.5.5 Skin Tissue Engineering. 18.5.6 Vascular Tissue Engineering. 18.5.7 Nerve Tissue Engineering. 18.6 Status and Prognosis. References. 19. Conducting Polymer Composites for Tissue Engineering Scaffolds: Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi. 19.1 Introduction. 19.2 Conducting Polymers. 19.3 Synthesis of Conducting Polymers. 19.4 Application of Conducting Polymer in Tissue Engineering. 19.5 Polypyrrole. 19.6 Poly(3,4-ethylene dioxythiophene). 19.7 Polyaniline. 19.8 Carbon Nanotube. 19.9 Future Prospects and Conclusions. Acknowledgements. References. 20. Cell Patterning Technologies for Tissue Engineering: Azadeh Seidi and Murugan Ramalingam. 20.1 Introduction. 20.2 Patterned Co-culture Techniques. 20.2.1 Substrate Patterning with ECM Components. 20.2.2 Microfluidic-based Patterning. 20.2.3 Switchable Surface-based Patterning. 20.2.4 Mechanical and Stencil-based Patterning. 20.2.5 3D Patterned Co-cultures. 20.3 Applications of Co-cultures in Tissue Engineering. 20.4 Concluding Remarks. Acknowledgements. References. Index.
Back to Top
BISAC SUBJECT HEADINGS
TEC059000: Technology & Engineering/Biomedical
TEC021000: Technology & Engineering/Materials Science
TEC027000: Technology & Engineering/Nanotechnology
BIC CODES
TCBS: Biosensors
TGM: Materials Science
TBN: Nanotechnology
Back to Top