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Submit a ProposalBehaviors and Persistence of Nanomaterials in Biomedical Applications
 | By Domenico Cassano and Valerio Voliani Series: Advances in Nanotechnology and Applications Copyright: 2018 | Status: Published ISBN: 9781119418276 | Hardcover | 258 pages | 62 illustrations Price: $195 USD  |
One Line Description
The use of nanomaterials in medicine has made great breakthroughs, but the obstacle right now is how to reduce the bad toxicological effects. This book comprehensively reviews strategies how nanomaterials can safely exit the organisms after the medicine has been administered.
Audience
The book will be read by researchers and scientists in academia and pharmaceutical companies. Nanotechnologists, materials scientists, biotechnologists, chemists, biomedical engineers will be especially interested.
The book will be read by researchers and scientists in academia and pharmaceutical companies. Nanotechnologists, materials scientists, biotechnologists, chemists, biomedical engineers will be especially interested.
Description
In the last two decades, several promising engineered nanomaterials that combine therapeutic features and imaging functionalities have been presented, but very few have arrived on the market. The purpose of this book is to collect and comprehensively discuss the advances in this current and exciting topic in order to promote and enhance its growth. In the first part, a general introduction about the main features of both organic and inorganic nanomaterials is provided. Then, the most promising and innovative applications for cancer treatment and diagnostic are introduced.
In the second part, an analysis of the nanomaterials in the market for healthcare applications is presented. The issue of unwanted accumulation of metals in organisms after the designed action is then discussed. Finally, the most recent progress in the design of nanomaterials that are able to escape from organisms after the selected action are comprehensively described, along with the future research potential of this exciting field.
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In the last two decades, several promising engineered nanomaterials that combine therapeutic features and imaging functionalities have been presented, but very few have arrived on the market. The purpose of this book is to collect and comprehensively discuss the advances in this current and exciting topic in order to promote and enhance its growth. In the first part, a general introduction about the main features of both organic and inorganic nanomaterials is provided. Then, the most promising and innovative applications for cancer treatment and diagnostic are introduced.
In the second part, an analysis of the nanomaterials in the market for healthcare applications is presented. The issue of unwanted accumulation of metals in organisms after the designed action is then discussed. Finally, the most recent progress in the design of nanomaterials that are able to escape from organisms after the selected action are comprehensively described, along with the future research potential of this exciting field.
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Author / Editor Details
Domenico Cassano obtained his MSc in physics in 2014 and he is currently a PhD student in Biophysical Sciences at Scuola Normale Superiore – Center for Nanotechnology Innovation, Istituto Italiano di Tecnologia (Pisa, Italy). His PhD project focuses on the development of novel disassembling nano-architectures for combined chemo/radiotherapy. The main aim of his project is to enable the translation of metal nanoparticles to the clinics, which is still hampered by the issue of persistence of metals in the organisms.
Domenico Cassano obtained his MSc in physics in 2014 and he is currently a PhD student in Biophysical Sciences at Scuola Normale Superiore – Center for Nanotechnology Innovation, Istituto Italiano di Tecnologia (Pisa, Italy). His PhD project focuses on the development of novel disassembling nano-architectures for combined chemo/radiotherapy. The main aim of his project is to enable the translation of metal nanoparticles to the clinics, which is still hampered by the issue of persistence of metals in the organisms.
Valerio Voliani received his PhD in Biophysics from Scuola Normale Superiore in 2006. He is currently a Researcher at the Center for Nanotechnology Innovation, Istituto Italiano di Tecnologia (Pisa, Italy). His efforts are devoted in filling the gap between inorganic nanomaterials and clinical applications. By applying the ultrasmall-in-nano approach he has developed the passion fruit-like nano-architectures: nature-inspired inorganic nanoparticles that jointly combine theranostic efficacy with excretion of the building blocks from organism. He is the recipient of an individual AIRC grant, and he is now working on innovative theranostics for neoplasms treatment. He was recognized by the International Association of Advanced Materials (IAAM) Scientist medal in 2016.
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Table of Contents
Preface
1 Introduction
2 Nanomaterials
2.1 Physical Properties of Nanomaterials
2.1.1 Thermodynamic Properties: Melting Point Depression and Superheating
2.1.2 Optical Properties
2.1.3 Magnetism
2.2 Nanomaterials: An Overview
2.2.1 Organic Nanoparticles
2.2.2 Inorganic Nanoparticles
References
3 Promising Applications in Medicine
3.1 Diagnostics
3.1.1 X-Ray Computed Tomography
3.1.2 Photoacoustic Imaging
3.1.3 Positron Emission Tomography
3.1.4 Magnetic Resonance Imaging
3.1.5 Raman-Based Diagnostics
3.2 Therapy
3.2.1 Chemotherapy
3.2.2 Hyperthermia
3.2.3 Radiotherapy
References
4 Interactions of Nanomaterials with Biological Systems
4.1 Cellular Level (in vitro)
4.1.1 Cellular Uptake and Intracellular Fate
4.1.2 Physio-Chemical Dependence of Nanomaterials Uptake
4.1.3 Cytotoxicity
4.2 Body Level (in vivo)
4.2.1 Blood Circulation
4.2.2 Immune/Inflammatory Response
4.2.3 Metabolism (RES, Degradation, Excretion and Persistence)
References
5 Nanomaterials in the Market or in the Way of
5.1 Approval Pipeline (FDA and EMA)
5.2 Nanotherapeutics
5.3 Nanodiagnostics
References
6 Avoiding the Persistence of Metal Nanomaterials
6.1 Ultrasmall-in-Nano Approach
6.2 Porphyrin-Based Nanomaterials
References
7 Conclusions and Perspectives
References
Index
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Preface
1 Introduction
2 Nanomaterials
2.1 Physical Properties of Nanomaterials
2.1.1 Thermodynamic Properties: Melting Point Depression and Superheating
2.1.2 Optical Properties
2.1.3 Magnetism
2.2 Nanomaterials: An Overview
2.2.1 Organic Nanoparticles
2.2.2 Inorganic Nanoparticles
References
3 Promising Applications in Medicine
3.1 Diagnostics
3.1.1 X-Ray Computed Tomography
3.1.2 Photoacoustic Imaging
3.1.3 Positron Emission Tomography
3.1.4 Magnetic Resonance Imaging
3.1.5 Raman-Based Diagnostics
3.2 Therapy
3.2.1 Chemotherapy
3.2.2 Hyperthermia
3.2.3 Radiotherapy
References
4 Interactions of Nanomaterials with Biological Systems
4.1 Cellular Level (in vitro)
4.1.1 Cellular Uptake and Intracellular Fate
4.1.2 Physio-Chemical Dependence of Nanomaterials Uptake
4.1.3 Cytotoxicity
4.2 Body Level (in vivo)
4.2.1 Blood Circulation
4.2.2 Immune/Inflammatory Response
4.2.3 Metabolism (RES, Degradation, Excretion and Persistence)
References
5 Nanomaterials in the Market or in the Way of
5.1 Approval Pipeline (FDA and EMA)
5.2 Nanotherapeutics
5.3 Nanodiagnostics
References
6 Avoiding the Persistence of Metal Nanomaterials
6.1 Ultrasmall-in-Nano Approach
6.2 Porphyrin-Based Nanomaterials
References
7 Conclusions and Perspectives
References
Index
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