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Submit a ProposalMulti-Drug Resistance in Cancer
 | Mechanism and Treatment Strategies Edited by Rishabha Malviya, Arun Kumar Singh and Deepika Yadav Copyright: 2023 | Status: Published ISBN: 9781394209217 | Hardcover | 213 pages Price: $195 USD  |
One Line Description
The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents.
Audience
This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.
This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.
Description
Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases.
Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming cancer drug resistance.
The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment.
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Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases.
Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming cancer drug resistance.
The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment.
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Author / Editor Details
Rishabha Malviya, PhD, is an associate professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University. He has authored more than 150 research/review papers for national/international journals of repute and has been granted more than 10 patents from various countries while a further 40 patents are published/under evaluation. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients.
Rishabha Malviya, PhD, is an associate professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University. He has authored more than 150 research/review papers for national/international journals of repute and has been granted more than 10 patents from various countries while a further 40 patents are published/under evaluation. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients.
Arun Kumar Singh has completed M. Pharm (pharmaceutics) from Galgotias University, Greater Noida, India. His areas of interest are in the area of nanoformulation, blockchain, IoT, machine learning, cancer, artificial intelligence, and big data.
Deepika Yadav completed M. Pharm from Galgotias University, Greater Noida, Uttar Pradesh. She has published several papers with reputed international publishers.
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Table of Contents
Foreword
Preface
Acknowledgment
1. Multi-Drug Resistance in Cancer: Understanding of Treatment Strategies
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
1.1 Introduction
1.2 Both Congenital and Developed Resistance to Drugs
1.2.1 Intrinsic Resistance
1.2.2 Acquired Resistance
1.3 Drug-Resistance Mechanisms
1.3.1 Increased Efflux of Drugs
1.3.2 Impact on Medication Target
1.3.3 Improved DNA-Damage Repair
1.4 Senescence Escape
1.5 Epigenetic Alterations
1.6 Tumor Heterogeneity
1.7 Tumor Microenvironment
1.8 Epithelial to Mesenchymal Transition
1.9 Conclusion
References
2. Understanding Different Mechanisms Involved in Cancer Drug Resistance: Proposing Novel Strategies to Overcome MDR
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
2.1 Introduction
2.2 Drug Resistance: Internal and External Variables
2.2.1 Phenotypic Variation of Tumors
2.2.2 Tumor Microenvironment
2.2.3 Cancer Stem Cells
2.2.4 Inactivation of the Anticancer Drugs
2.2.5 Multi-Drug Resistance
2.2.6 Increasing the Release of Drugs Outside the Cell
2.2.7 Reducing the Absorption of the Drugs
2.2.8 Inhibition of Cell Death (Apoptosis Pathway Blocking)
2.3 Improving the Pharmacokinetics
2.4 Changing the Aim of the Chemotherapy Agents
2.5 Improving the DNA Repair Process
2.5.1 Augmentation of a Gene
2.5.2 Epigenetic Altering Caused Drug Resistance
2.6 MicroRNA in Cancer Drug Resistance
2.7 Conclusion
References
3. Molecular Mechanism of Multi-Drug Resistant Cancer Cells
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
3.1 Introduction
3.2 Types of Drug Resistance
3.3 Mechanisms of Drug Resistance
3.3.1 Drug Efflux via ABC Transporters
3.3.2 Permeability Glycoprotein/MDR-1
3.3.3 Multi-Drug Resistance Protein
3.3.4 Breast Cancer Resistance Protein
3.4 Reduction in Drug Activity and Cellular Absorption
3.5 Instability in the Genome and Medication Resistance
3.5.1 Mutation and Medication Target Alteration
3.5.2 Restoration of DNA Integrity
3.5.3 Resistant Genes and Epigenetic Modifications
3.5.4 Drug Resistance and Programmed Cell Death
3.6 RNA Interference Therapy
3.7 Methods of Physical Intervention to Treat MDR
3.8 Conclusion
References
4. Natural Products for Clinical Management of Drug Resistant Cancer Cells
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
4.1 Introduction
4.2 Resistance Mechanisms
4.3 Antitumor Plants for Multi-Drug-Resistant Cells
4.4 Qualea Species and Their Medical Applications
4.5 Antitumor Activity of Qualea Grandiflora and Qualea Multiflora
4.6 Conclusion
References
5. Understanding of Autophagy to Combat MDR During Anticancer Therapy
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
5.1 Introduction
5.2 Mechanisms of Autophagy
5.2.1 Phagophore Assembly
5.2.2 Autophagosome Formation and Maturation
5.2.3 Autolysosome Degradation
5.2.4 Core Regulator of Autophagy
5.3 Mechanisms of MDR
5.4 Correlation Between Autophagy and Multi-Drug Resistance
5.5 The Cytoprotective Effect of Autophagy in the Regulation of Multi-Drug Resistance
5.6 Increased Autophagy Facilitates Multi-Drug Resistance
5.7 Autophagy Inhibition Improves Chemotherapy in MDR Cancers
5.8 Overcoming MDR With Autophagic Cell Death
5.9 Autophagy Kills Apoptosis-Deficient MDR Cancer Cells
5.10 Autophagy Promotes Chemosensitivity
5.11 Conclusion
References
6. Transporter Inhibitors: A Chemotherapeutic Regimen to Improve the Clinical Outcome of Colorectal Cancer
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
6.1 Introduction
6.2 CRC Transporters or ATP-Binding Cassette
6.2.1 ABC Transporter Family
6.2.2 ABC Transporters and CRC Initiation
6.2.3 ABC Transporters and the Resistance of Cancer Cells to Chemotherapy
6.3 Clinical Evidence for the Function of ABC Transporters in CRC MDR
6.3.1 Intrinsic Drug Resistance in Colon Cancer Upregulation of P-gp at Detection
6.3.2 Proliferating Tumor Cells Have MRP1 on Their Surface
6.4 General Approaches
6.5 By Blocking Tyrosine Kinase Inhibitors from Inhibiting MDR Transporters
6.6 Components Produced from Natural Sources that Inhibit MDR Transporters
6.7 Inhibiting ABC Transporters in Other Ways for CRC MDR Circumvention
6.8 Challenges and Future Prospective
6.9 Conclusion
References
7. Epithelial to Mesenchymal Transition (EMT): Major Contribution to Cancer Drug Therapy Resistance
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
7.1 Introduction
7.2 EMT and Tumor Resistance: In Vitro, In Vivo, and Clinical Trials
7.3 Tumor Microenvironment Regulates EMT
7.3.1 Hypoxia
7.3.2 The Extracellular Matrix
7.3.3 The Inflammatory and Immune Microenvironment
7.3.4 EMT Microenvironment: Medication Resistance
7.4 Drug Resistance and EMT Bioinformatics
7.4.1 Bioinformatics and Pharmacogenomics to Optimize Drugs and Targets and Identify Medication Resistance
7.4.2 Drug Resistance: Hereditary or Acquired
7.4.3 Therapies for EMT-Induced Medication Resistance
7.5 Conclusion
References
8. Advances in Metallodrug-Driven Combination Therapy for Treatment of Cancer 155
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
8.1 Introduction
8.2 Cancer Treatment Using Combination Therapy
8.3 Combined Treatment with Metallodrugs for Cancer Treatment
8.3.1 Platinum Metallodrugs
8.4 Nonplatinum Metallodrugs
8.5 Conclusion
References
9. Novel Strategies Preventing Emergence of MDR in Breast Cancer
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
9.1 Introduction
9.2 Breast Cancer Categorization and Epidemiological Studies
9.2.1 Treatment Options for Women With Breast Cancer
9.3 Multi-Drug Resistance in Breast Cancer
9.3.1 Breast Cancer Chemoresistance
9.3.2 Multi-Drug Resistance and ABC Channels in Breast Cancer
9.4 Drug Efflux Transporters in Breast Cancer
9.4.1 Exocytosis Transporters in the Stem Cell Population of Breast Cancer
9.4.2 Drug Efflux Channel Upregulation in Breast Cancer
9.4.3 Techniques for Breast Cancer MDR Reversal
9.4.4 Direct Pharmacologic Inhibition With MDR Inhibitors
9.5 Excessive Synthesis or Overexpression of Transporters for the Expulsion of Drugs
9.6 Nanotherapeutic Approach for MDR Reversal
9.7 Breast Cancer’s MDR Cure Problems and Future Outlook
9.8 Conclusion
References
Index
Back to Top
Foreword
Preface
Acknowledgment
1. Multi-Drug Resistance in Cancer: Understanding of Treatment Strategies
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
1.1 Introduction
1.2 Both Congenital and Developed Resistance to Drugs
1.2.1 Intrinsic Resistance
1.2.2 Acquired Resistance
1.3 Drug-Resistance Mechanisms
1.3.1 Increased Efflux of Drugs
1.3.2 Impact on Medication Target
1.3.3 Improved DNA-Damage Repair
1.4 Senescence Escape
1.5 Epigenetic Alterations
1.6 Tumor Heterogeneity
1.7 Tumor Microenvironment
1.8 Epithelial to Mesenchymal Transition
1.9 Conclusion
References
2. Understanding Different Mechanisms Involved in Cancer Drug Resistance: Proposing Novel Strategies to Overcome MDR
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
2.1 Introduction
2.2 Drug Resistance: Internal and External Variables
2.2.1 Phenotypic Variation of Tumors
2.2.2 Tumor Microenvironment
2.2.3 Cancer Stem Cells
2.2.4 Inactivation of the Anticancer Drugs
2.2.5 Multi-Drug Resistance
2.2.6 Increasing the Release of Drugs Outside the Cell
2.2.7 Reducing the Absorption of the Drugs
2.2.8 Inhibition of Cell Death (Apoptosis Pathway Blocking)
2.3 Improving the Pharmacokinetics
2.4 Changing the Aim of the Chemotherapy Agents
2.5 Improving the DNA Repair Process
2.5.1 Augmentation of a Gene
2.5.2 Epigenetic Altering Caused Drug Resistance
2.6 MicroRNA in Cancer Drug Resistance
2.7 Conclusion
References
3. Molecular Mechanism of Multi-Drug Resistant Cancer Cells
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
3.1 Introduction
3.2 Types of Drug Resistance
3.3 Mechanisms of Drug Resistance
3.3.1 Drug Efflux via ABC Transporters
3.3.2 Permeability Glycoprotein/MDR-1
3.3.3 Multi-Drug Resistance Protein
3.3.4 Breast Cancer Resistance Protein
3.4 Reduction in Drug Activity and Cellular Absorption
3.5 Instability in the Genome and Medication Resistance
3.5.1 Mutation and Medication Target Alteration
3.5.2 Restoration of DNA Integrity
3.5.3 Resistant Genes and Epigenetic Modifications
3.5.4 Drug Resistance and Programmed Cell Death
3.6 RNA Interference Therapy
3.7 Methods of Physical Intervention to Treat MDR
3.8 Conclusion
References
4. Natural Products for Clinical Management of Drug Resistant Cancer Cells
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
4.1 Introduction
4.2 Resistance Mechanisms
4.3 Antitumor Plants for Multi-Drug-Resistant Cells
4.4 Qualea Species and Their Medical Applications
4.5 Antitumor Activity of Qualea Grandiflora and Qualea Multiflora
4.6 Conclusion
References
5. Understanding of Autophagy to Combat MDR During Anticancer Therapy
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
5.1 Introduction
5.2 Mechanisms of Autophagy
5.2.1 Phagophore Assembly
5.2.2 Autophagosome Formation and Maturation
5.2.3 Autolysosome Degradation
5.2.4 Core Regulator of Autophagy
5.3 Mechanisms of MDR
5.4 Correlation Between Autophagy and Multi-Drug Resistance
5.5 The Cytoprotective Effect of Autophagy in the Regulation of Multi-Drug Resistance
5.6 Increased Autophagy Facilitates Multi-Drug Resistance
5.7 Autophagy Inhibition Improves Chemotherapy in MDR Cancers
5.8 Overcoming MDR With Autophagic Cell Death
5.9 Autophagy Kills Apoptosis-Deficient MDR Cancer Cells
5.10 Autophagy Promotes Chemosensitivity
5.11 Conclusion
References
6. Transporter Inhibitors: A Chemotherapeutic Regimen to Improve the Clinical Outcome of Colorectal Cancer
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
6.1 Introduction
6.2 CRC Transporters or ATP-Binding Cassette
6.2.1 ABC Transporter Family
6.2.2 ABC Transporters and CRC Initiation
6.2.3 ABC Transporters and the Resistance of Cancer Cells to Chemotherapy
6.3 Clinical Evidence for the Function of ABC Transporters in CRC MDR
6.3.1 Intrinsic Drug Resistance in Colon Cancer Upregulation of P-gp at Detection
6.3.2 Proliferating Tumor Cells Have MRP1 on Their Surface
6.4 General Approaches
6.5 By Blocking Tyrosine Kinase Inhibitors from Inhibiting MDR Transporters
6.6 Components Produced from Natural Sources that Inhibit MDR Transporters
6.7 Inhibiting ABC Transporters in Other Ways for CRC MDR Circumvention
6.8 Challenges and Future Prospective
6.9 Conclusion
References
7. Epithelial to Mesenchymal Transition (EMT): Major Contribution to Cancer Drug Therapy Resistance
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
7.1 Introduction
7.2 EMT and Tumor Resistance: In Vitro, In Vivo, and Clinical Trials
7.3 Tumor Microenvironment Regulates EMT
7.3.1 Hypoxia
7.3.2 The Extracellular Matrix
7.3.3 The Inflammatory and Immune Microenvironment
7.3.4 EMT Microenvironment: Medication Resistance
7.4 Drug Resistance and EMT Bioinformatics
7.4.1 Bioinformatics and Pharmacogenomics to Optimize Drugs and Targets and Identify Medication Resistance
7.4.2 Drug Resistance: Hereditary or Acquired
7.4.3 Therapies for EMT-Induced Medication Resistance
7.5 Conclusion
References
8. Advances in Metallodrug-Driven Combination Therapy for Treatment of Cancer 155
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
8.1 Introduction
8.2 Cancer Treatment Using Combination Therapy
8.3 Combined Treatment with Metallodrugs for Cancer Treatment
8.3.1 Platinum Metallodrugs
8.4 Nonplatinum Metallodrugs
8.5 Conclusion
References
9. Novel Strategies Preventing Emergence of MDR in Breast Cancer
Rishabha Malviya, Arun Kumar Singh and Deepika Yadav
9.1 Introduction
9.2 Breast Cancer Categorization and Epidemiological Studies
9.2.1 Treatment Options for Women With Breast Cancer
9.3 Multi-Drug Resistance in Breast Cancer
9.3.1 Breast Cancer Chemoresistance
9.3.2 Multi-Drug Resistance and ABC Channels in Breast Cancer
9.4 Drug Efflux Transporters in Breast Cancer
9.4.1 Exocytosis Transporters in the Stem Cell Population of Breast Cancer
9.4.2 Drug Efflux Channel Upregulation in Breast Cancer
9.4.3 Techniques for Breast Cancer MDR Reversal
9.4.4 Direct Pharmacologic Inhibition With MDR Inhibitors
9.5 Excessive Synthesis or Overexpression of Transporters for the Expulsion of Drugs
9.6 Nanotherapeutic Approach for MDR Reversal
9.7 Breast Cancer’s MDR Cure Problems and Future Outlook
9.8 Conclusion
References
Index
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